阿尔茨海默病患者血清脑源性神经营养因子水平研究

Serum brain-derived neurotrophic factor levels in Alzheimer's disease

目的探讨阿尔茨海默病(AD)与血清脑源性神经营养因子(BDNF)水平的关系。方法采用酶联免疫吸附法对46例AD患者(研究组)和44例正常对照者(对照组)的外周血清进行BDNF水平检测。所有受试者均进行简易精神状态量表(MMSE)、Hachinski缺血指数(HIS)及汉密尔顿抑郁量表(HAMD)评定,AD患者用临床痴呆评定量表(CDR)进行痴呆严重程度分级。结果研究组血清BDNF水平低于对照组(P<0.01)。研究组轻度、中度与重度AD患者血清BDNF水平均低于对照组(P<0.01),重度AD血清BDNF水平低于轻度AD(P<0.05)。研究组血清BDNF水平与年龄、病程呈负相关(P<0.01),与MMSE评分呈正相关(P<0.01)。结论 AD患者存在血清BDNF水平降低,且与其年龄、病程及痴呆程度显著相关。

Objective To explore the correlation between level of serum brain-derived neurotrophic factor （BDNF） and Alzheimer＇s disease （AD）. Methods Serum level of BDNF were measured in 46 patients with AD （study gorup） and 44 healthy controls （control group ） by enzyme-linked immnnosorbant assay. All subjects were assessed with Mini Mental State Examination （MMSE） , Haehinski [schemie Score （HIS） and Hamilton Depression Scale （HAMD） . The severity of AD was evaluated according to Clinical Dementia Rating Scale （CDR）. Results Serum level of BDNF were significantly lower in AD patients than that in control group （P 〈 0.01）. Serum BDNF level in patients with mild AD, moderate AD and severe AD were all significantly lower than that in control group （ P 〈 0.01 ）. Serum BDNF level in patients with severe AD was significantly lower than that in mild AD （ P 〈 0.05 ）. Serum BDNF level in study group was significantly negatively correlated with age and duration （ P 〈 0.01 ）, and was significantly positively correlated with score of MMSE （ P 〈 0.01 ）. Conclusions Serum level of BDNF is low in patients with AD and is correlated with age, duration and the severity of AD.