精神分裂症患者肌酸激酶同工酶电泳及其临床价值

Electrophoresis of serum creatine kinase isoenzyme in schizophrenic patients and its clinical application

目的探讨精神分裂症患者肌酸激酶(CK)同工酶电泳的特点及临床意义。方法对57例CK升高的精神分裂症患者、21例CK正常的精神分裂症患者及21例健康对照者的血清作CK同工酶电泳,采用速率法对CK及肌酸激酶同工酶MB(CK-MB)进行活性检测,采用简明精神病评定量表(BPRS)对患者进行评分。结果 57例精神分裂症患者中47例电泳阴性,有9例患者检出巨CK1,1例患者检出CK-BB,在9例泳出巨CK1的患者中有1例同时有异常升高CKMB组分。所有研究对象中均未发现巨CK2。CK正常患者组及健康对照组同工酶电泳结果为阴性。结论肌酸激酶升高的精神分裂症患者其同工酶主要组分为来自于骨骼肌的CK-MM,巨CK1的检出为良性现象,与精神分裂症患者疾病特点相关。

Objective To investigate electrophoresis features of serum creatine kinase （CK） isoenzymes and its clinical significance in schizophrenia. Methods CK isoenzymes were electrophoresed in 57 schizophrenic patients with elevated CK, 21 schizophrenic patients with normal CK and 21 healthy controls. Total CK and the activity of CK-MB were detected by using performance rate method. All patients were assessed with Brief Psychiatric Rating Scale （BPRS）. Results 47 cases among 57 schizophrenic patients with elevated CK showed negative electrophoresis. CK-BB was found in 1 case and macro CK type I was found in 9 cases, in which one patient had elevated CK-MB subunit. There was no macro CK type Ⅱ in all subjects involved in the study. Result of CK isoenzymes electrophoresis was negative in 21 schizophrenic patients with normal CK and 21 healthy controls. Conclusion The main component of CK isoenzymes is CK-MM originated from skeletal muscle in schizophrenic patients with elevated CK. Macro CK type I is considered as a kind of benign phenomenon and may be associated with the characteristics of schizophrenia.