慢性阻塞性肺疾病患者IL-6与sIL-6R受体的表达及意义

目的探讨慢性阻塞性肺疾病（COPD）患者白细胞介素-6（IL-6）与可溶性白细胞介素-6（sIL-6R）受体的表达及意义。方法选取COPD患者60例，其中COPD急性期和缓解期患者各30例，分别采用ELISA检查血清IL-6与sIL-6R水平。结果COPD急性期患者IL-6、sIL-6R水平显著高于缓解期患者，两组比较差异有统计学意义（P=0．041）。急性期COPD患者中，吸烟者IL-6、sIL-6R水平显著高于不吸烟者（P=0．040）。缓解期COPD患者中，吸烟者IL-6、sIL-6R水平显著高于不吸烟者（P=0．018）。血清IL-6、sIL-6R与用力肺活量（FVC）、1s用力呼气容积（FEV1）、FEV1％、FEV1／FVC呈显著负相关。结论IL-6与sIL-6R水平在判断COPD发展、转归及预后上具有重要意义。

Objective To evaluate the clinical significance and expression of intedeukin-6 （ IL-6 ） and soluble interleukin-6 receptor （ sIL-6R ） in patients with chronic obstructive pulmonary disease （ COPD ） . Selected 60 patients with COPD as the research object. Used ELISA examination for serum IL-6 and sIL-6R level. Results The levels of serum IL-6 and sIL-6R in patients with acute exacerbation of COPD were significantly higher than that in patients with remission of COPD, the difference was statistically significant （ P=0.041 ） . In acute exacerbation of COPD group, the levels of serozn IL-6 and sIL-6R in smokers were significantly higher than that in non-smokers （ P=0.040 ） . In remission of COPD group, the level of serum IL-6 and sIL-6R in smokers were significantly higher than that in non-smokers （ P=-0.018 ） . Serum IL - 6 and sIL-6R with FVC, FEV1, FEV1 and FEV1 / FVC % were significantly negative correlation. Conclusion The detection of serum IL - 6 and sIL-6R plays an important role in the development, outcome and prognosis of COPD.