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蛋白酪氨酸磷酸酶1B(PTP1B)抑制剂的研究进展 被引量：4

Research Progress on Inhibitors of Protein Tyrosine Phosphatase 1B( PTP1B)
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摘要 2型糖尿病是一种代谢综合症,其特点是胰岛素抵抗、高胰岛素血症、高血糖。研究表明,蛋白酪氨酸磷酸酶1B(PTP1B)是胰岛素转导信号的负调节因子,已经是治疗2型糖尿病和肥胖症的一个新的靶点。PTP1B抑制剂能够有效地治疗2型糖尿病和肥胖症。本文综述了近年来PTP1B抑制剂的研究进展。 Type 2 diabetes is a metabolic syndrome,which character is insulin resistance,hyperinsulinemia and hyperglycemia.Protein tyrosine phosphatase 1 B（PTP1B）,a negative regulator of insulin signal trans-duction,is a new target for type 2 diabetes and obesity drug discovering.PTP1B inhibitors can effectively treat type 2 diabetes and obesity.This paper summarizes the research progress of PTP1B inhibitors in re-cent years.
作者 杨猛 高天虹
机构地区 青岛科技大学化工学院
出处 《河南化工》 CAS 2015年第1期11-15,共5页 Henan Chemical Industry
基金 国家自然科学基金(41206066)
关键词 2型糖尿病 蛋白酪氨酸磷酸酶1B PTP1B抑制剂 type 2 diabetes protein tyrosine phosphatase 1B PTP1B inhibitors
分类号 TQ463 [化学工程—制药化工]
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参考文献19

  • 1Ram Weiss, Andrew A Bremer, Robert H Lustig. What is metabolic syndrome, and why are children getting it? [J]. Ann N Y Acad Sci,2013,28:123 -140.
  • 2Verbeeten K C, Elks C E, Daneman D, et al. Association between childhood obesity and subsequent type 1 diabetes a systematic review and meta- analysis [ J ]. Diabet Med, 2011,28(1) :10 - 18.
  • 3Mehran A E,Templeman N M, Beigidi G S,et al. Hyper- insulinemia drives diet- induced obesity independently of brain insulin production [ J ]. Cell Metabolism, 2012,16 (6) :723 -737.
  • 4Walchli S, Curchod M L, Gobert R P, et al. Identification of tyrosine phosphatasesthat dephosphorylate inseulin re- ceptor. A brute force approach based on "substratetrap- ping" mutants [ J ]. The Joumal of Biological Chemistry, 2000,275 ( 13 ) :9792 - 9796.
  • 5Cicirelli M F. Microinjection of a proteintyrosine phospha- tase inhibits insulin action in Xenopus oocytes [ J ]. Pro- ceedings of the National Academy of Sciences USA, 1990, 87(14) :5514 -5517.
  • 6Elchebly M,Payette P, Michaliszyn E, et al. Increased in- sulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase- 1B[J]. Science, 1999,283 (5407) : 1544 - 1548.
  • 7孙良鹏,姜哲,高立信,李英哲,孙立云,李佳,朴虎日.含3,4-二氢-2(1H)-喹啉酮结构查尔酮衍生物的合成及蛋白酪氨酸磷酸酯酶1B抑制活性研究[J].有机化学,2012,32(11):2108-2114. 被引量：7
  • 8Dai Houling, Gao Lixin, Yang Ying, et al. Discovery of di - indolinone as novel scaffold for protein tyrosine phos- phatase 1B inhibitors [ J ]. Biooraganic Med Chem, Lett, 2012,22:7440 - 7443.
  • 9史大永,许凤,李敬,郭书举,苏华,韩丽君.海藻中溴酚化合物的蛋白酪氨酸磷脂酶1B抑制活性研究[J].中国中药杂志,2008,33(19):2238-2240. 被引量：7
  • 10Jing Li,Shu Ju Guo,Hua Su,Li Jun Han,Da Yong Shi.Total synthesis of bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane as potent PTP1B inhibitor[J].Chinese Chemical Letters,2008,19(11):1290-1292. 被引量：6

二级参考文献48

  • 1曾向潮,徐石海,李毅群,施文兵,邓芹英.N-(2-吡咯甲酰基)氨基酸甲酯的合成[J].有机化学,2004,24(7):802-805. 被引量：22
  • 2刘家峰,郭松坡,姜标.海洋溴吡咯生物碱的研究进展[J].有机化学,2005,25(7):788-799. 被引量：13
  • 3葛海霞,王礼琛.2(1H)-喹啉酮类化合物的药理活性及构效关系[J].药学进展,2005,29(7):309-316. 被引量：15
  • 4曾向潮,徐石海,李毅群,王渝芳.Aldisin及其衍生物的合成和α-葡萄糖苷酶抑制活性研究[J].有机化学,2005,25(8):954-958. 被引量：5
  • 5Johnson TO,Ermolieff J,Jirousek MR.Protein tyrosine phosphates 1B inhibitors for diabetes[J].Nat Rev Drug Discov,2002,2:696-709.
  • 6Elchebly M,Payette P,Michaliszyn E,et al.Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene[J].Science,1999,283:1544-1548.
  • 7Klaman LD,Boss O,Peroni OD,et al.Increased energy expenditure,decreased adiposity,and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice[J].Mol Cell Biol,2000,20:5479-5489.
  • 8Swarbrick MM,Havel PJ,Levin AA,et al.Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys[J].Endocrinology,2009,150:1670-1679.
  • 9Lantz KA,Hart SG,Planey SL,et al.Inhibition of PTP1B by trodusquemine(MSI-1436)causes fat-specific weight loss in diet-induced obese mice[J].Obesity,2010,18:1516-1523.
  • 10Combs AP.Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes,obesity,and cancer[J].J Med Chem,2010,53:2333-2344.

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河南化工
2015年 第1期

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