64层螺旋CT灌注成像早期诊断直肠癌术后复发的价值

The value of 64-slice spiral CT perfusion technique in early diagnosis of rectal carcinoma recurrence lesion

目的探讨64层螺旋CT灌注成像在直肠癌术后复发及瘢痕组织的血流灌注情况,为早期诊断直肠癌术后复发提供诊断依据。方法 30例直肠癌患者,术前及术后6个月均行64层螺旋CT灌注成像。计算感兴趣区组织血流量(BF)、血容量(BV),平均通过时间(MTT)和血管表面通透性。比较正常直肠与肿瘤组织、术后复发肿瘤组织与瘢痕组织各灌注参数的差别。结果与正常直肠组织相比,直肠癌组织BF值明显升高、MTT值明显降低,结果差异有统计学意义。而与瘢痕组织相比,术后复发肿瘤组织BF值明显升高、MTT值明显降低。结论 64层螺旋CT灌注成像能有效鉴别直肠癌患者术后复发肿瘤组织与瘢痕组织,对早期诊断直肠癌术后复发具有重要价值。

Objective Using 64-slice spiral CT perfusion technique to investigate blood perfusion in recurrence lesion and scar tissue, to provide the basis of early diagnosing recurrence lesion in rectal carcinoma. Methods Perfusion CT of rectal carcinoma was performed with 64-slice spiral CT in 30 patients with rectal carcinoma before surgery and about 6 months after surgery, tissue blood flow （BF）, blood volume （BV）, mean transit time （MTT）, and vascular permea- bility surface were acquired. The perfusion parameters of normal rectal tissue, preoperative primary tumor, local soft tissue density after surgery （recurrence or scar tissue） were compared. Results The primary rectal carcinoma and the recur- rence lesion showed higher BF and shorter MTT compared with those of normal rectum. The recurrence lesion showed significant increase in BF and reduction in MTT values than the scar tissue. Conclusion 64-slice spiral CT perfusion technique is useful in distinguishing recurrence lesion and scar tissue; therefore it has important value for early diagnosing recurrence lesion of rectal carcinoma.