男性吸烟者血清endocan水平与冠心病发病的关系

Correlation between serum endocan concentration and the presence of coronary artery disease in male smokers

目的评价男性吸烟者血清endocan水平与冠心病发病的关系。方法 2012-08~2014-08纳入176名男性吸烟者,分为冠心病组（CAD,n=84）及非冠心病组（non-CAD,n=92）,测两组的基线临床资料及血清endocan水平,通过logistic回归分析评价各指标与冠心病发病的独立相关性。结果 CAD组患者血清血清endocan水平较non-CAD组显著升高[1.49（0.76-1.86）ng/L vs 0.77（0.32-1.10）ng/L,P〈0.01]。多元Logistic回归分析显示血清endocan水平与男性吸烟者合并冠心病呈独立正相关（优势比1.86,95%CI 1.17-2.75,P〈0.01）。结论血清endocan水平是预测男性吸烟者罹患冠心病的独立危险因子。

Objective To evaluate the correlation between serum endocan concentrations and the presence of coronary artery disease （CAD） in male smokers. Methods From August 2012 to August 2014, 176 male smokers were enrolled in this study. All the smokers were divided to CAD group（n = 84） and non-CAD group（ n = 92）. Clinical baselines and serum endocan concentrations were determined in the two groups. The correlation between clinical variables and the presence of CAD was analyzed by Logistic analysis. Results Serum endocan concentrations were significantly higher in CAD group than in non-CAD group [ 1.49 （0.76 - 1.86）ng/L vs 0.77（0.32 -1.10） ng/L,P 〈0.01 ]. Multiple Logistic analysis revealed that serum endocan concentrations were independently corre- lated with the presence of CAD in male smokers（OR = 1.86,95%CI 1.17 -2.75, P〈0. 01）. Conclusion Endocan in serum may be an independent risk factor for predicting the development of CAD in male smokers.