黄连素联合益肝灵治疗代谢综合征合并非酒精性脂肪性肝炎的临床观察

Observation of the clinical effects of berberine combined with Yi-gan-Ling in the treatment of metabolize syndrome with nonalcoholic steatohepatitis

目的研究黄连素(盐酸小檗碱,Berberine,BBR)联合益肝灵对代谢综合征(metabolic syndrome,MS)合并非酒精性脂肪肝炎(Non-alcoholic steatohepatitis,NASH)的疗效和安全性。方法将96例符合MS合并NASH诊断标准的患者,按随机数字表法分为治疗组和对照组,治疗组用黄连素和益肝灵治疗,对照组用阿卡波糖和益肝灵治疗,疗程均为3个月。在治疗前后分别检测C-反应蛋白(C-RP)、糖化血红蛋白(Hb A1C)、空腹胰岛素(FINS)、空腹血糖(FPG)、餐后2 h血糖(2h PG)、血脂(TG、TC、HDL-C、LDL-C)和肝功能(GGT、ALT、AST)。结果经3个月治疗后,两组患者的C-RP、Hb A1C、FINS、FPG、2h PG、IRI、血脂和肝功能均有不同程度的改善,但治疗组明显优于对照组,(P<0.01或P<0.05),两组的总有效率分别为85.4%和60.4%,两组比较差异均有统计学意义(P<0.05)。结论我们的研究结果表明,黄连素联合益肝灵治疗MS合并NASH是有效、安全、可靠的,并且费用低廉,值得进一步推广应用。

Objective To study the efficacy and safety of berberine combined with Yi-Gan-Ling in the treatment of metabolize syndrome complicated with non-alcoholic steatohepatitis.Methods 96 patients with metabolize syndrome complicated with non-alcoholic steato-hepatitis were divided into treatment group and control group by random number table method, with treatment group taking berberine combined with Yi-Gan-Ling and control group taking acarbose combined with Yi-Gan-Ling.Both groups were treated for three months. Serum C-RP, HbA1 C, FINS, FPG, 2hPG, blood lipids and liver function were examined before and after treatment.Results After three-month treatment, C-RP, HbA1 C, FINS, FPG etc.were all improved in both groups, but treatment group was superior to control group （P〈0.01 or P〈0.05）.The total effective rates were 85.4% and 60.4% in treatment and control group, respectively, with significant differences （ P〈0.05） .Conclusions Our results show that combination of berberine with Yi-Gan-Ling in the treatment of metabolize syndrome complicated with non-alcoholic steatohepatitis is efficacious, safe, reliable and low-cost.It deserves popularization.