自拟复方中药联合替吉奥治疗晚期结直肠癌疗效观察

Self-made Compound Chinese Medicine Combined with Gimeracil and Oteracil Porassium Capsules for the Treatment of Advanced Colorectal Cancer

目的:观察自拟复方中药联合替吉奥治疗晚期结直肠癌的临床疗效及毒副反应。方法:选择晚期结直肠癌术后化疗患者40例,随机分为治疗组和对照组各20例,治疗组采用自拟复方中药联合替吉奥治疗,对照组单纯采用FOLFOX4方案化疗。比较两组患者化疗前后生存质量改善情况、血清肿瘤标记物(CEA、CA19-9、CA72-4)、肿瘤坏死因子-α(TNF-α)及白介素-12(IL-12)含量以及血常规、肝肾功及心电图等相关检查指标的变化情况。结果:经过治疗,治疗组在降低血清肿瘤标记物CEA、CA19-9,优于对照组,且可明显改善患者生存质量,治疗组化疗后TNF-α及IL-12升高,而对照组降低,组间比较差异有统计学意义(P<0.05)。结论:自拟复方中药联合替吉奥对化疗毒副反应具有一定的防治作用,并能降低血清肿瘤标记物水平,同时可以改善患者临床症状和机体一般状况,值得临床推广应用。

Objective： To observe the effect and toxicity of the regimen of Self-made compound chinese medicine combined with chemotherapy scheme of gimeracil and oteracil porassium capsules （S-1） for the treatment of advanced colorectal cancer. Methods ： Forty advanced colorectal cancer patients after doing colorectal operation were selected and divided into two groups randomly. The twenty patients in the treat group were treated with Self-made compound chinese medicine combined with gimeracil and oteracil po- rassium capsules （S-1） chemical therapy and the twenty patients in the control group were treated simply with FOLFOX4 chemical therapy. The seriousness of the adverse effects during the chemical therapy,alleviation of clinical symptoms, of serum tumor indica- ting（CEA,CA19-9,CA72-4） , Tumor necrosis factor alpha （TNF -α） and interleukin 12 （IL-12） content,the target of liver and kid- ney function, blood routine, ECG,. were compared and the differences were analysed by statistics. Results：The serum level of CEA, CA19-9, The treatment group can obviously improve the quality of survival, is better than the control group. Levels of TNF-α and IL-12 significantly elevated in the test group after treatment but lowered in the control group, showing significant difference between groups（both P〈 0. 05）. Conclusion： Self-made compound chinese medicine combined with oteracil porassium capsules chemical therapy has remarkable therapeutic effect Oil reducing adverse effects,it can reduce serum tumor indicating, and it Can improve clini- cal symptoms and common conditions.