腺苷蛋氨酸联合前列腺素E1治疗重度黄疸型肝炎疗效研究

Study on Efficacy of Ademetionine Combined with Prostaglandin E1 in the Treatment of Severe Hepatitis with Jaundice

目的:探讨腺苷蛋氨酸联合前列腺素E1治疗重度黄疸型肝炎的临床疗效。方法:选取重度黄疸型肝炎患者98例,随机分为实验组和对照组各49例,在常规护肝治疗措施基础上,实验组患者给予腺苷蛋氨酸和前列腺素E1治疗,对照组患者仅给予前列腺素E1治疗。观察并比较两组患者肝功能指标改善情况以及疗效。结果:实验组患者总有效率为85.7%,对照组患者总有效率为53.1%,实验组患者疗效明显优于对照组,两组比较差异有统计学意义(P<0.05);治疗后实验组与对照组相比,ALT、AST和TBil下降最为明显(P<0.01),ALP和γ-GT下降差异有统计学意义(P<0.05)。结论:腺苷蛋氨酸联合前列腺素E1治疗重度黄疸型肝炎疗效确切,值得临床推广应用。

Objective： To evaluate the effectiveness of ademetionine combined with prostaglandin E1 in the treatment of severe hepatitis with jaundice. Methods： Selected patients with severe icteric hepatitis in 98 cases, were randomly divided into experimental group and control group with 49 cases in each group, treatment based on conventional liver protecting, the patients in the experimen- tal group received ademetionine and prostaglandin E1 treatment, the control group were only given prostaglandin E1 treatment. To observe and compare the biochemical indices of liver function improvement and effect. Results： The patients in the experimental group the total efficiency of 85.7%, patients in the control group the total effective rate was 53.1 %, the patients in the experimental group were significantly better than the control group, there was significant difference between two groups （P〈0. 05）; after the treatment, the experimental group compared with the control group, ALT, AST and TBil decreased significantly （P〈0. 0l）, ALP and gamma -GT decreased the difference was statistically significant （P〈 0.05）. Conclusion： The efficacy of ademetionine com- bined with prostaglandin E1 in the treatment of severe hepatitis with jaundice, which is worthy of clinical application.