线粒体外膜通道蛋白VDAC与靶向肿瘤细胞凋亡

Voltage-dependent Anion Channel in OMM as the Target in Cancer Cell Apoptosis

VDAC(Voltage-dependent anion channel)是位于线粒体外膜上的一种主要通道蛋白,参与线粒体内外物质和能量的运输,在线粒体与细胞其它部位的通讯中起重要调节作用.近年来研究发现,VDAC也是线粒体与其它蛋白质相互作用的功能结合位点,可与多种凋亡调节蛋白(如HK-Ⅰ/Ⅱ、Bcl-2家族蛋白、tubulin、MAP2/4等)以及非蛋白调节因子相互作用,参与调控细胞凋亡.因此,VDAC成为线粒体凋亡通路中一种关键的靶蛋白.本文对近年来VDAC在肿瘤细胞凋亡中的作用机制进行简要综述.

VDAC（voltage-dependent anion channel）is the porin,which primarily lies in the outer mitochondrial membrane（OMM）,and is responsible for the influx and efflux of metabolites.As a result,VDAC plays important roles in coordination between mitochondria and other cell compartments in cell communication.Recently it has been found that VDAC also functions as the docking site for the proteins interaction with mitochondria.It interacts with various apoptotic regulators（HK-Ⅰ/Ⅱ、Bcl-2family members、tubulin、MAP2/4and so on）and non-protein factors involved in modulating cell apoptosis.Therefore,VDAC becomes the key protein and the target of drug molecules in mitochondrial apoptotic pathway.This paper briefly reviews the recent developments of VDAC in regulating cancer cell apoptosis.