六君子丸联合四联疗法提高脾胃虚弱型Hp感染者根除率的研究

Six Gentlemen pill combined with quadruple therapy to improve the rate oferadication of spleen and stomach type Hp infection

目的探究六君子丸联合四联疗法治疗脾胃虚弱型幽门螺旋杆菌(Hp)感染者的临床效果。方法选取2010年8月—2013年5月在我院就诊的600例因Hp感染引发消化性溃疡的患者,其中脾胃虚弱型Hp感染者72例,将其随机分为对照组和观察组,每组36例。对照组采用四联疗法,观察组在此基础上加用六君子丸,观察比较两组患者的治疗效果及Hp根除率。结果对照组总有效率为88.9%,观察组总有效率为91.7%,两组的总有效率差异无统计学意义(P>0.05);对照组患者Hp根除率为66.7%,观察组患者Hp根除率为83.3%。观察组Hp根除率明显高于对照组,具有统计学意义(P<0.05)。结论采用六君子丸联合四联疗法能够显著提高脾胃虚弱型Hp感染者的根除率,值得临床借鉴使用。

Objective To explore the Six Gentlemen pill combined with quadruple therapy treatment weakness of spleen and stomach Helicobacter pylori（Hp） infection the clinical effect. Methods From 2010 August to 2013 May in our hospital 600 cases of patients with Hp infection caused by peptic ulcer, the weakness of spleen and stomach of Hp infection in 72 cases, which were randomly divided into control group and observation group, each group of 36 cases. The control group using quadruple therapy,observation group based on the use of Six Gentlemen pill, to observe the therapeutic effect of two groups were compared and the Hp eradication rate. Results The control group the total effective rate was 88.9%, total effective rate of observation group was91.7%, the effective rates of two groups had no significant difference（P〉0.05）; the control group of patients with Hp eradication rate was 66.7%,the observation group of patients with Hp eradication rate was 83.3%. The observation group Hp eradication rate was significantly higher than the control group, with statistical significance（P〈0.05）.Conclusion The Six Gentlemen pill combined with quadruple therapy can significantly improve the eradication rate of spleen and stomach type Hp infection, worthy of clinical use.