克林霉素治疗小儿支原体肺炎的疗效分析

Analysis of the Curative Effect of Clindamycin in the Treatment of Mycoplasma Pneumonia in Children

目的探讨和研究克林霉素治疗小儿支原体肺炎的临床疗效。方法摘取该院自2009年1月—2013年1月之间所收治的88例支原体肺炎患儿的临床资料作为对象进行研究,按照随机分组的方式将以上患儿分为观察组44例和对照组44例,其中对照组单纯采用阿奇霉素进行治疗,观察组则在此基础上加用克林霉素进行治疗,对两组患儿的疗效进行统计对比。结果疗效显示观察组的总有效率为95.5%与显效率61.3%均显著优于对照组的81.8%、36.3%,差异有统计学意义(P<0.05),从不良反应方面来看,观察组6.8%对照组9.1%,对比差异无统计学意义(P>0.05)。结论克林霉素治疗小儿支原体肺炎的疗效显著,联合阿奇霉素应用的效果显著优于单纯采用阿奇霉素进行治疗,值得在临床上加以推广和应用。

Objective To investigate and study the clinical efficacy of clindamycin in the treatment of mycoplasma pneumonia in children. Methods The clinical data of 88 children with mycoplasma pneumonia admitted in our hospital from January 2009 to January 2013 were selected as the subjects. And the children were randomly divided into the observation group and the control group with 44 children in each. The control group was treated by azithromycin, and the observation group was treated by clindamycin on the basis of azithromycin. The efficacies of the two groups of children were counted and compared. Results The efficacies of the groups showed that the total effective rate and markedly effective rate of the observation group was 95.5%, 61.3%, respectively, higher than 81.8%, 36.3% of the control group, respectively, the differences were statistically significant（P〈0.05）. The incidence of adverse reactions of the observation group was 6.8%, and that of the control group was 9.1%, the difference was not statistically significant（P〉0.05）. Conclusion Clindamycin is quite effective in the treatment of children with mycoplasma pneumonia. The effect of clindamycin combined with azithromycin is much better than that of azithromycin, and it is worthy of promotion and application in clinical practice.