普瑞巴林联合星状神经节阻滞用于带状疱疹后遗神经痛的临床研究

Clinical Study on the Effect of Pregabalin Combined with Stellate Block in the Treatment of Postherpetic Neuralgia

目的分析普瑞巴林联合星状神经节阻滞用于带状疱疹后遗神经痛的临床效果。方法选取该院收治的带状疱疹后遗神经痛患者共84例,随机将其分成观察组和对照组各42例,其中对照组患者采用普瑞巴林治疗,观察组患者在对照组基础上联合星状神经节阻滞治疗,对两组患者用药后1、2、3、4周疼痛视觉模拟评分变化进行对比分析,同时对比分析两组患者治疗总有效率。结果治疗前两组患者VAS评分均差异无统计学意义,治疗28 d后观察组患者VAS评分明显低于对照组患者,差异有统计学意义(P<0.05),具有可比性。经过不同治疗后,观察组患者治疗总有效率为95.24%(40/42),对照组患者治疗总有效率为73.81%(31/42),差异有统计学意义(P<0.05)。结论在对带状疱疹后遗神经痛患者进行治疗的过程中,采用普瑞巴林联合星状神经节阻滞治疗,能够有效缓解带状疱疹后遗神经痛,同时具有起效快、治疗效果好等诸多优点,能够进一步提升患者的生活质量使睡眠障碍得到有效改善。

Objective To analyze the clinical effect of pregabalin combined with stellate block in the treatment of postherpetic neuralgia.Methods A total of 84 cases with postherpetic neuralgia admitted in our hospital were selected and randomly divided into the observation group and the control group with 42 cases in each.The control group was treated with pregabalin,and the observation group was treated with pregabalin combined with stellate block.The changes in the visual analogue scale（VAS） score after the treatment of 1,2,3,4 weeks,and the total effective rate were compared and analyzed between the two groups.Results Two groups of patients had no significant difference in VAS score before treatment,but 28 d after treatment,the VAS score of the observation group was significantly lower than that of the control group with statistical significance（P〈0.05） and comparability.After different treatment,the total effective rate of the observation group was 95.24%（40/42）,and that of the control group was 73.81%（31/42）,with statistical significance（P〈0.05） and comparability.Conclusion For the treatment of patients with postherpetic neuralgia,pregabalin combined with stellate block can relieve the postherpetic neuralgia with rapider onset and better treatment effect and other advantages,and further improve the quality of life as well as the sleep disorder of the patients effectively.