丹参多酚酸盐对ACS患者血清炎性因子及临床疗效的影响

Effects of Salvianolate on the Efficacies and Serum Inflammatory Factors in ACS Patients

目的探讨丹参多酚酸盐治疗急性冠脉综合征(ACS)的临床疗效,以及对患者血清超敏C反应蛋白(hs-CRP)及肿瘤坏死因子-α(TNF-α)水平的影响。方法选择符合标准的患者80例,随机分为观察组40例和对照组40例,所有患者均给予常规治疗,观察组加用丹参多酚酸盐,观察比较两组患者治疗前临床症状、血清hs-CRP及TNF-α变化。结果入院时两组患者血清hs-CRP及TNF-α水平相似,差异无统计学意义(P>0.05);治疗7 d、14 d,两组患者血清hs-CRP及TNF-α水平较入院时均下降,差异有统计学意义(P<0.05),但是观察组较对照组下降更显著(P<0.05)。观察组患者显效30例、有效9例和无效1例,对照组患者显效20例、有效10例和无效10例,差异有统计学意义(P<0.05)。结论丹参多酚酸盐可有效降低ACS患者血清hs-CRP及TNF-α水平,减轻炎症反应程度,改善患者临床症状,值得临床推广应用。

Objective To investigate the clinical efficacies of salvianolate in the treatment of acute coronary syndrome （ACS） and the effects of it on the serum levels of hypersensitive C reaction protein （hs-CRP） and tumor necrosis factor-α（TNF-α） in the pa-tients. Methods 80 eligible patients were selected and randomly divided into observation group and control group, with 40 patients in each group. All the patients were given the conventional therapies, but the patients of the observation group were given sal-vianolate additionally. And the changes in clinical symptoms and serum TNF-α and hs-CRP levels were observed and compared. Results On admission, the patients of the two groups had similar serum TNF-α and hs-CRP levels, and the differences were not statistically insignificant （P〉0.05）. At 7d and 14d after the therapies, the serum TNF-αand hs-CRP levels in the patients of both groups were decreased when compared with those on admission, and the differences were statistically significant （P〈0.05）, but they were decreased more significantly in the patients of the observation group （P〈0.05）. Of the observation group, 30 patients were re-sponsive to the therapies excellently, 9 patients were responsive effectively, and 1 patient was unresponsive; while of the control group, 20 patients were responsive to the therapies excellently, 10 patients were responsive effectively, and 10 patients were unre-sponsive;and the difference was statistically significant（P〈0.05）. Conclusion Salvianolate can effectively decrease the serum TNF-α and hs-CRP levels, lighten the degree of inflammatory reaction, and improve the clinical symptoms in ACS patients, and conse-quently is worthy of clinical application.