薄膜包衣厚度测量方法分析

Analysis of Measuring Methods for Coating Thickness of Thin Film

随着包衣机和薄膜包衣技术的发展,薄膜包衣已经成为片剂包衣的主流,其中包衣厚度是衡量包衣效果的重要指标,直接影响到药品质量的好坏。本研究对薄膜包衣厚度的显微图像测量法,近红外光谱法,拉曼光谱法,X射线荧光光谱法以及太赫兹光谱方法进行了简要的分析,并比较了各种测量方法的优缺点。结果证明:太赫兹光谱方法最为有效。

With the development of coating machine and film coating technology, film coating has become the mainstream of tablet coating. Coating thickness is an important index to measure the coating effect, and affects the quality of drug directly. In this paper, microscopic image measurement method, near infrared spectroscopy method, Raman spectroscopy, X-ray fluorescence spectroscopy and terahertz spectroscopy method of film coating thickness are briefly analyzed, and we compared the advantages and disadvantages of various methods of measurement. The results show that terahertz spectroscopy method is the most effective method.