口底恶性副神经节瘤1例

A cases report of malignant paraganglioma of mouth floor

目的探讨口底恶性副神经节瘤的临床表现、病理特征和治疗方法。方法报道口底恶性副神经节瘤1例,患者女,30岁,主诉"发现口底区肿胀1月余,影响言语及吞咽"入院,诊为口底肿物,全麻下行口底肿物切除术,完整切除肿瘤。结果术后病理确诊为口底恶性副神经节瘤,本例口底恶性副神经节瘤为无功能性,免疫组化结果为CK(-)、EMA(+)、Vim(+)、Des(-)、myo D1少量弱(+)、S-100(+)、GFAP弱(+)、syn(+)、CGA(+)、NSE(+)、NF(-)、CD34(-)、actin(弱+),PAS染色(-)。术后10 d拆线出院。结论口底恶性副神经节瘤缺乏特异的临床特征表现,易误诊,只有靠切除术后病理和免疫组化才能确诊。由于其非常罕见,相关治疗缺乏成熟的经验,故需要进一步研究。

Objective Objective To investigate the clinical presentation, pathologic features and treatment of malignant paraganglioma of mouth floor. Methods We retrospectively studied a case of malignant paraganglioma of mouth floor. A 30-year-old woman with swell of the mouth floor for over 1month was admitted to the hospital. After diagnosed as having tumor of the mouth floor, she underwent resection operation and the tumor was completely removed. Results Postoperative pathological examination confirmed the tumor to be malignant paraganglioma, which was non-functional, with the immunohistochemical results of CK（-）, EMA（＋）, Vim（＋）, Des（-）, myo D1（weak ＋）, S-100（＋）,GFAP（weak ＋）, syn（＋）, CGA（＋）, NSE（＋）, NF（-）, CD34（-）, actin（weak ＋）, PAS（-）. The patient had stitches out and discharged 10 days post-operation. Conclusion Lacking specific clinical characteristics,malignant paraganglioma of the mouth floor is easily misdiagnosed, and can be confirmed only by postoperative pathology and immunohistochemistry. For the treatment of this rare tumor, little experience has been accumulated, and further studies are needed.