两种硝呋太尔制剂对妊娠期滴虫性阴道炎的疗效比较研究

A comparative study on the curative effect of two kinds of Nifuratel prepa-ration on gestational trichomonal vaginitis

目的比较两种硝呋太尔制剂对妊娠期滴虫性阴道炎的疗效,以优化治疗方案。方法选择笔者医院2013年1月—2014年1月妊娠期滴虫性阴道炎患者190例作为研究对象,随机分为观察组(n=95)和对照组(n=95)。观察组采用硝呋太尔口服制剂疗法,对照组采用硝呋太尔制霉素阴道软胶囊治疗。评价两组患者的临床疗效、不良反应和复发情况。结果观察组患者治疗总有效率为100%,显著高于对照组(93.7%)(P<0.05)。两组患者不良反应率差异无统计学意义(P>0.05);随访6个月内,观察组和对照组的复发率分别为1.1%和37.9%,差异具有统计学意义(P<0.01)。结论硝呋太尔口服制剂用于治疗妊娠期滴虫性阴道炎,总体疗效优于硝呋太尔制霉素阴道软胶囊。

Objective To compare the efficacy of two kinds of Nifuratel preparation for trichomonal vaginitis in pregnancy, in order to optimize the treatment plan. Methods From January 2013 to January 2014, 190 cases of pregnant patients with trichomonas vaginitis in our hospital was as the research objects, randomly divided into observation group （n=95） and control group （n=95）. The observation group was treated with Nifuratel oral therapy and the control group was treated with Nifuratel nysfungin vaginal soft capsule. Clinical efficacy, adverse reactions and recurrence of the two groups were evaluated. Results In the observation group, the total effective rate was 100%, significantly higher than that of the control group （93.7%） （P〈0.05）. It showed no statistical signifi- cance between the two groups in adverse reaction rate （P〉0.05）. after six months of follow-up, the recurrence rate of the observation group and control group were 1.1% and 37.9%, and the difference was statistically significant （P〈0.01）. Conclusion The overall effect is better for Nifnratel oral preparation treating trichomonal vaginitis in pregnancy than Nifuratel nysfungin vaginal soft capsule.