NICU中新生儿重度高胆红素血症的换血治疗

Exchange transfusion in the treatment of NICU in neonates with severe hyperbilirubinemia

目的探讨NICU中新生儿重度高胆红素血症换血治疗的应用及效果。方法选取2013年1月—2014年3月该院新生儿监护病房收治的重度高胆红素血症新生儿57例,采用外周动静脉同步换血方式进行治疗,换血中密切监测患者生命体征、血糖等指标变化,并在结束治疗后进行血常规、血生化等检查比较。结果所有患儿经换血治疗后血清总胆红素和间接胆红素等均显著下降,6例患儿出现贫血,22例患儿出现血小板减少,49例患儿出现高血糖症,无血钙、血钠及血钾异常改变。结论在新生儿重度高胆红素血症临床治疗过程中,采用外周动静脉同步换血治疗可有效降低血清胆红素,同时对患儿不良反应少,值得在临床上进行推广和应用。

Objective To investigate the application and effect of NICU in neonates with severe hyperbilirubinemia exchange transfusion therapy. Methods From 2013 January to 2014 March in our hospital neonatal intensive care ward in neonates with severe hyperbilirubinemia in 57 cases, the peripheral arteriovenous synchronous exchange transfusion for exchange transfusion, closely monitoring changes in patients with vital signs, blood glucose and other indicators, and at the end of treatment of blood routine,biochemical examination. Results All patients after exchange transfusion on serum total bilirubin and indirect bilirubin decreased significantly, 6 cases of anemia, 22 cases of thrombocytopenia, 49 cases of hyperglycemia, abnormal changes without serum calcium, sodium and serum potassium. Conclusion In severe neonatal hyperbilirubinemia in clinical treatment process, using the peripheral arteriovenous synchronous exchange transfusion treatment can effectively reduce serum bilirubin, and with less side effect,it is worth of promotion and application in clinical practice.