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肾脏替代治疗时抗生素的应用 被引量:1

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摘要 肾脏替代治疗(renal replacement therapy,RRT)已广泛应用于危重症伴或不伴急性肾损伤(acute renal injury,AKI)或慢性肾衰竭(chronic renal failure,CRF)患者[1-2].RRT除了有效清除机体的代谢产物和毒素外,也可导致药物剂量不足,尤其是抗感染药物浓度的不足引起感染的复发和耐药菌株的产生[3],并使得抗感染药物药代动力学更加复杂.如何调整接受RRT治疗患者抗感染药物的使用剂量值得关注,因此优化RRT患者的抗菌素治疗方案对于改善预后及降低药物不良反应可起到关键的作用.
作者 查艳 张湘燕
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2015年第1期7-10,共4页 Chinese Journal of Tuberculosis and Respiratory Diseases
基金 国家自然科学基金(81200539)
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