普罗布考联用阿托伐他汀对急性脑梗死患者脂质代谢的影响

Effect of combined probucol and atorvastatin on lipid metabolism in acute ischemic stroke patients

目的观察普罗布考联合用阿托伐他汀对急性脑梗死患者脂质代谢的影响。方法将84例急性脑梗死患者随机分为对照组40例(阿托伐他汀20mg/d)和观察组44例(阿托伐他汀20mg/d;普罗布考500mg/d,2次/d),治疗4个月后随访。分别于治疗前及治疗4个月后测2组血脂、高敏C反应蛋白(hs-CRP)水平,并进行神经功能缺损程度评分。结果 2组治疗4个月后较治疗前TC、TG、LDL-C、氧化低密度脂蛋白(ox-LDL)和hs-CRP水平均明显降低,HDL-C明显增高,神经功能缺损评分减小(P<0.05,P<0.01);观察组治疗4个月后较对照组TC、TG、LDL-C、ox-LDL、hs-CRP及神经功能缺损评分明显降低(P<0.05,P<0.01)。结论普罗布考联合阿托伐他汀治疗急性脑梗死有协同调脂、抗氧化及抗炎作用,其比阿托伐他汀单独应用能有效提高近期疗效。

Objective To observe the clinical effect of combined probucol and atorvastatin on lipid metabolism in acute ischemic stroke （AIS） patients. Methods Eighty-four AIS patients were ran- domly divided into control group （n=40） and combined probucol and atorvastatin treatment group （n=44）. Patients in control group were treated with atorvastatin （20 rag/d） while those in coinbined probucol and atorvastatin treatment group were treated with probucol （20 rag/d） and atorv astatin （500 mg/d）,twice a day for 4 months. The serum levels of lipid and hs-CRP were measured and the neurological deficiency score was recorded before and 4 months after treatment. Results The serum levels of TC, TG, LDI. C, ox-LDL and hs-CRP were significantly lower, the serum HDL-C level was significantly higher and the the neurological deficiency score was signifi cantly lower in two groups after treatment than before treatment （P〈0.05 ,P〈0.01 ）. Conclusion Combined probucol and atorvastatin exerts a synergical effect on lipid metabolism,oxidation and inflammation,and its short term effect is better than that of atorvastatin alone in AIS patients.