射频消融联合靶向治疗非小细胞肺癌患者生命质量的影响

Effect of radiofrequency ablation combined with targeted therapy on quality of lifein the treatment of patients with non-small cell lung cancer

目的研究超声与CT引导下导管射频消融(radiofrequency ablation,RFA)对靶向联合化学药物治疗周围型中晚期非小细胞肺癌患者生命质量的影响。方法选取90例诊断为周围型中晚期非小细胞癌的患者随机分为治疗组与对照组,每组均为45例。两组患者均给予吉非替尼联合顺铂与紫杉醇靶向治疗,治疗组在靶向化学联合治疗的基础上,行在超声与CT引导下经皮射频消融术,治疗前及治疗后4周评价两组患者的生命质量并记录不良反应。结果治疗后两组的整体功能、特异性症状各个指标及整体生命质量评分均明显优于治疗前,且治疗后治疗组上述治疗指标均优于对照组(P<0.05),治疗组治疗后出现咳嗽、胸痛、发热、咯血、气胸,两组患者治疗后均出现恶心、伴呕吐、骨髓抑制,且无统计学差异(P>0.05)。结论射频消融术联合靶向与化学治疗能改善转移灶较少的周围型中晚期非小细胞肺癌患者的生命质量。

Objective To study the effect of radiofrequency ablation combined with targeted therapy under CT and ultrasound on quality of life in the treatment of patients with non-small cell lung cancer. Methods 90 NSCLC patients at stage Ⅲ and Ⅳ were randomly divided into the treatment group and the control group. All of them were treated with paelitaxel, cisplatin and gefitinib, and the treatment group was added with CT or ultrasound guided percutaneous radiofrequency ablation. Their quality of life before and 4 weeks after the treatment were compared and the adverse reactions were recorded. Results After the treatment, the allomeric function and the scores of symptom specific modules turned better （ P 〈 0.05 ）, and the improvement was more pronounced in the treatment group than in the control group （ P 〈 0. 05 ）. There was no significant difference in cough, chest pain, febrile, hemoptysis, pneu- mothorax nausea, vomit and myelosuppression between the two groups. Conclusion Radiofrequency ablation guided by ultrasound and CT combined with targeted therapy and chemotherapy can improve quality of life of patients with peripheral non-small cell lung cancer at stage Ⅲ and Ⅳ.