不同剂量右旋美托咪定的镇静效果及其对呼吸循环的影响

Sedative effect of different doses of dexmedetomidine and its effect on respiratory and circulatory system

目的探讨不同剂量右旋美托咪定的镇静效果及其对机体呼吸循环系统的影响。方法选择30名支气管镜检查患者并随机分为3组,每组患者选择不同剂量Dex(0.5、1.0及1.5μg/kg)静脉注射,观察Dex的临床效应及这种效应是否为浓度依赖性。结果注射后即产生明显的镇静效应,表现为警觉/镇静评分明显降低(P<0.05),并伴随心率下降(P<0.05),15 min后受试者出现血氧饱和度降低(P<0.05)。同时亦可降低三组受试者的血压(P<0.05),但三组起效的起始时间不同。剂量因素、时间和剂量的交互因素差异无统计学意义(P>0.05)。结论静脉注射0.5-1.5 ug/kg Dex,出现明显的镇静效应,且在15 min内完成检查最佳,同时Dex能有效降低受试者的血压、血氧饱和度及心率,这种效应非药物浓度依赖性,但随着药物量的增加,其恢复时间随之延长。

Objective To explore the sedative effect of different doses of dexmedetomidine and its effect on respiratory and circulatory system. Methods 30 bronchoscopy patients were randomly divided into three groups to be given a different dose of dexmedetomidine intravenously （0.5, 1.0 and 1.5 μg/kg）. Their clinical effect was ob- served. Results Dexmedetomidine had a significant inhibitory effect, which the score of OAA/S was significantly lower and the heart rate also decreased （P 〈 0. 05 ）. The subjects appeared the reduction of blood oxygen saturation 15 minutes after dexmedetomidine injection （ P 〈 0. 05 ）, and dexmedetomidine also showed antihypertensive effect （P 〈 0. 05 ） , but the initial effective time was different. There was no significant difference in does-effect and dosetime interaction （ P 〉 0. 05 ）. Conclusion All the patients have sedative effect when they are injected 0.5 - 1.5 μg/kg dexmedetomidine. This check could be better in 15 minutes. At the same time, dexmedetomidine could effectively reduce blood pressure, oxygen saturation and heart rate.