小儿咳嗽变异性哮喘与肺炎支原体感染的关系及大环内酯类药物治疗的效果

Relationship between cough variant asthma and mycoplasma pneumoniae infection and effect of macrolide drugs in the treatment of CVA

目的探讨小儿咳嗽变异性哮喘(CVA)与肺炎支原体感染的关系以及大环内酯类药物对CVA治疗的疗效。方法选择我院60例CVA患儿作为研究组,同期就诊的60例上呼吸道感染患儿为对照组,检测并比较两组患者血清MP-Ig M,研究组MP-Ig M阳性及阴性血清血嗜酸粒细胞计数及血清总Ig E水平。统计研究组31例并MP感染患儿使用大环内酯类药物治疗疗效。结果研究组患儿血清MP-Ig M阳性率为51.67%,明显高于对照组11.67%,比较差异具有统计学意义(P<0.05);研究组MP-Ig M阳性患儿血清总Ig E及嗜酸粒细胞计数分别为(197.45±60.56)U/m L和(0.48±0.04)×109/L,均明显高于MP-Ig M阴性患儿,比较差异具有统计学意义(P<0.05);31例CVA并MP感染患儿经大环内酯类药物治疗后,治疗有效率为93.55%。结论小儿CVA与肺炎支原体感染密切相关,使用大环内酯类药物对其治疗疗效显著,值得推广应用。

Objective To explore the relationship between cough variant asthma and mycoplasma pneumoni-ae infection and to evaluate the curative effect of macrolide drugs in the treatment of CVA. Methods 60 children with CVA in our hospital were selected as the study group, and another 60 children with respiratory tract infection were taken as the control group at the same period. Their serum MP-IgM, eosinophil count and IgE levels were detec-ted and compared. The curative effect of macrolide drugs was evaluated. Results The positive rate of MP-IgM was 51. 67% in the study group, which was significantly higher than in the control group （11. 67%） （P〈0. 05）. The levels of serum total IgE and eosinophils granulocyte count were （197. 45 ± 60. 56） U/mL and （0. 48 ± 0. 04） × 109/L in the study group, which were significantly higher than those in the control group （P〈0. 05）. The effective rate of macrolide drugs in 31 cases of MP infection of CVA children was 93. 55%. Conclusion Cough variant asthma is closely related to mycoplasma pneumoniae infection and macrolide drugs has a significant effect in the treatment of CVA.