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百草枯中毒患者肺泡灌洗液中骨桥蛋白及TGF-β的变化

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摘要 目的探讨百草枯中毒患者肺泡灌洗液中骨桥蛋白(osteopontin OPN)及转化生长因子β(βtransform growth factor-βTGF-β)的变化。方法百草枯中毒患者和对照组各11例,取肺泡灌洗液检测OPN及TGF-β水平。结果百草枯中毒患者肺泡灌洗液中OPN及TGF-β水平明显高于对照组。结论百草枯中毒患者肺泡灌洗液中OPN及TGF-β水平明显升高,可能是引起肺损伤的原因。
出处 《临床肺科杂志》 2015年第3期552-553,共2页 Journal of Clinical Pulmonary Medicine
基金 韶关市科学技术项目(No卫2010-6)
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  • 1Pardo A, Gibson K, Cisneros J, et al. Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis [ J ]. PLOS Meal,2005,2(9) :891 -903.
  • 2Serlin D M, Kuang P P, Subramanian M, et al. Interleukin- 1 [3induces osteopontin expression in pulmonary fibrosis [ J]. J Cell Biochem,2006,97 ( 3 ) : 519 - 529.
  • 3Kohan M, Bader R, Puxeddu I, et al. Enhanced osteopontin expres- sion in a murine model of allergen-induced airway remodeling [J]. Clin Exp Allergy ,2007,37 (10) : 1444 - 1454.
  • 4Takahashi F,Takahashi K, Okazaki T, et al. Role of osteopontin in the pathogenesis of bleomycin-induced pulmonary fibrosis[ J ]. Am J Respir Cell Mol Biol,2001,24 ( 3 ) :264 - 271.
  • 5Rossouw DJ, Chase CC, Engelbrecht FM. Experimental paraquat poisoning-histological, electron,microscopic and autoradioraphic changes in the lung[J]. S Mr Med J, 198,4,66(13) :485-489.
  • 6Suntres ZE. Role of antioxidants in paraquat toxicity [ J ]. Toxicology,2002,180( 1 ) :65 - 77.
  • 7Manoury B, Nenan S, Leclerc O, et al, The absence of reactive oxygen species production protects mice against bleomycin - induced pulmonary [J]. Respir Hes,2005,6( 1 ) : 11 - 19.
  • 8Hayashi T, Stetlet Stevenson WG, Fleming MV, et al. Immunohischemical study of metalloproteinases and their tissue inhibitors in the lung of patients with diffuse alveolar damage and idiopathic pulmonary fibmsis[J]. Am J Pathol,1996,149:1241-1256.
  • 9Lapptdainen U, Whitsett JA, Wert SE, et al. Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung[J]. Am J Respir Cell Mol Biol,2005,32(4) :311-318.
  • 10Pardo A, Perez Ramos J, Segura Valdez L, et al. Expression and localization of TIMP-1, TIMP-2, MMP-13, MMP-2,and MMP-9 in early and advanced exprimental lung silicosis[J]. Ann NY Acad Sci,1999,878:587-589.

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