早产儿血清脂联素与骨密度的关系

Relationship between serum adiponectin and bone mineral density in preterm infants

目的：检测早产儿血清脂联素水平，探讨早产儿血清脂联素与骨密度的关系。方法共选取72例新生适于胎龄儿为研究对象，根据胎龄分为早期早产儿组（31-33＋6周，13例）、晚期早产儿组（34-36＋6周，16例）、足月儿组（37-42周，43例）。生后1周内采集静脉血测定血清脂联素水平；同时行超声定量技术测量左侧胫骨声波的传导速度（SOS）来评估骨密度。结果早期早产儿组胫骨SOS值低于晚期早产儿组和足月儿组，晚期早产儿组胫骨SOS值低手足月儿组，差异均具有统计学意义（P〈0.05）。早期早产儿组血清脂联素水平低于晚期早产儿组和足月儿组，晚期早产儿组血清脂联素水平低手足月儿组，差异均具有统计学意义/（P〈0.05）。早产儿血清脂联素水平与胫骨SOS值呈正相关（r=0.664，P〈0.05）。多元线性回归分析显示血清脂联素和出生体重是早产儿胫骨SOS值的独立影响因素。结论早产儿血清脂联素水平低手足月儿，与早产儿骨密度呈正相关。

Objective To examine serum adiponectin level in preterm infants and to evaluate the relationship between serum adiponectin and bone mineral density in preterm infants. Methods Seventy-two appropriate-for-gestational-age neonates were classiifed into three groups according to their gestational ages：early preterm （31-33＋6 weeks, 13 cases）, late preterm （34-36＋6 weeks, 16 cases）, and full-term （37-42 weeks, 43 cases）. Venous blood was collected at one week of their life to measure serum adiponectin concentration. During the period, omnisense ultrasound bone sonometer was applied to measure speed of sound （SOS） of the left tibia. Results The median of tibia SOS in the early preterm group was signiifcantly lower than in the late preterm and full term groups （P〈0.05）, and the median of tibia SOS in the late preterm group was lower than in the full-term group （P〈0.05）. Serum adiponectin level was lowest in the early preterm group, and the full-term group had the highest serum adiponectin level. Serum adiponectin level was positively correlated with tibia SOS in preterm infants （r=0.664, P〈0.05）. According to the result of multivariate linear stepwise regression analysis, serum adiponectin and birth weight were independent predictor of tibia SOS in preterm infants. Conclusions Serum adiponectin level is lower in preterm infants than that in full-term infants. There is a positive correlation between serum adiponectin and bone mineral density in preterm infants.