孤独症谱系障碍患儿血清25(OH)D水平的检测

Serum levels of 25-hydroxyvitamin D in children with autism spectrum disorders

目的：了解孤独症谱系障碍（ASD）患儿维生素D营养状况，探讨维生素D水平与ASD的关系。方法采用高效液相色谱-串联质谱法对117例新诊断的ASD患儿和109例健康对照儿童进行血清25（OH）D检测，并根据血清25（OH）D水平，将维生素D状况分为正常（〉30 ng/mL）、不足（10-30 ng/mL）和缺乏（〈10 ng/mL），比较两组儿童维生素D营养状况。结果 ASD患儿25（OH）D水平（19±9 ng/mL）明显低于对照组（36±13 ng/mL），差异有统计学意义（P〈0.01）。ASD患儿中维生素D缺乏和不足率为89.7%，明显高于对照组（52.3%），差异有统计学意义（P〈0.01）。结论 ASD患儿存在维生素D缺乏或不足，维生素D缺乏和不足有可能是ASD发病的环境/遗传因素。

Objective To examine serum 25-hydroxyvitamin D levels in children with autism spectrum disorders （ASD） and to explore the relationship between vitamin D level and ASD. Methods Serum levels of 25-hydroxyvitamin D levels were determined by the HPLC-MS/MS method in 117 children with newly diagnosed ASD and 109 healthy controls. Vitamin D status were classified into normal （〉30 ng/mL）, insufficiency （10-30ng/mL） and deficiency （〈10 ng/mL） according to 25-hydroxyvitamin D levels. Results Serum level of 25-hydroxyvitamin D （19±9 ng/mL） in children with ASD was signiifcantly lower than that in healthy controls （36±13 ng/mL;P〈0.01）. The rate of vitamin D insufifciency plus deifciency in the ASD group was signiifcantly higher than in the control group （89.7%vs 52.3%;P〈0.01）. Conclusions Vitamin D insufifciency or deifciency is common in children with ASD and might be as one of the environmental or genetic factors for ASD.