4-(3H)-喹唑酮Co(Ⅱ)、Ag(Ⅰ)配合物的合成、晶体结构、荧光和抗癌活性

Syntheses, Structures, Fluorescence and Anticancer Activity of Co(Ⅱ) and Ag(Ⅰ) Complexes with 4-(3H)-Quinazolinone

以4(3H)-喹唑酮、Co(NO3)2·6H2O、Ag NO3为原料,在相同物料比、溶剂和常温条件下,合成了配合物[Co(L)2·(H2O)2·(NO3)2](1)和[Ag(L)2·(NO3)](2)(L=4-(3H)-喹唑酮)。对其进行了X-射线单晶衍射表征和热重分析。X-射线单晶衍射分析表明,它们都属于三斜晶系,但1是六配位,2是三配位的。还测定了2的固体荧光和抗癌活性。配合物2的最大发射波长比配体红移了27 nm,其对NCI(人非小细胞肺癌细胞)有较好的抗癌作用。

Complexes [Co（L）2（H2O）2（NO3）2] （1） and [Ag（L）2（NO3）] （2） were synthesized （L=4-（3H）-quinazolinone）, and were both characterized by single crystal X-ray diffraction analysis and thermogravimetric analysis. Single crystal X-ray diffraction analysis showed that they all belong to triclinic space group, but 1 is six-coordinated and 2 is three-coordinated. Meanwhile, the solid-state fluorescence and anticancer activity of 2 also were studied.