摘要
合成和表征了一种苯并噻唑类的荧光探针（YH1）,并用光谱法研究了它对不同金属离子的响应.结果表明：YH1对Hg^2＋显示出好的选择性和灵敏度,与Hg^2＋作用后,在紫外光的激发下它的溶液颜色由蓝色变为无色.在1.4～8.8 μmol.L^-1浓度的范围内,YH1的荧光强度与Hg^2＋浓度有线性关系,其对Hgg^2＋的检出限为0.56 μmol·L^-1.此外,YH1可跨过细胞膜,细胞毒性低,还可应用于HeLa活细胞中对Hg^2＋进行荧光成像.
A benzothiazole-derived fluorescent probe （YH1） has been synthesized and structurally characterized, and its response to different metal ions has been investigated by spectrometry. The results showed that YH1 exhibited good sensitivity and selectivity to Hg^2＋. Its interaction with Hg^2＋ caused the color of its solution changed from blue to colorless under UV irradiation. There was a good linear relationship between the fluorescence intensity of YH1 and the concentration of Hg^2＋ in the range of 1.4 μmol·L^-1 to 8.8μmol·L^-1, and its detection limit for Hg^2＋ was 0.56μmol·L^-1. Moreover, the cell membrane penetration of YH1 had low eytotoxieity, and it can be applied to image intracellular Hg^2＋ in living HeLa cells.
出处
《无机化学学报》
SCIE
CAS
CSCD
北大核心
2015年第2期361-368,共8页
Chinese Journal of Inorganic Chemistry
基金
湖北省教育厅B类项目(No.B20114404)
矿区环境污染控制与修复湖北省重点实验室开放基金项目(No.2012103)
湖北省教育厅青年人才资助项目(No.Q20132901)
