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动脉钙化:一种慢性炎症性疾病 被引量：12

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摘要 数十年前即已观察到动脉钙化,将其视为与衰老相关的被动现象,是矿物质代谢发生紊乱的一种进行性疾病.血管系统的异位钙化主要累及主动脉、冠状动脉和外周动脉.既往认为动脉钙化是磷酸钙晶体被动沉积于斑块所致,现已明确其发生发展类似于胚胎骨形成的主动调节过程[1-2].动脉钙化和动脉粥样硬化具有相同的危险因素包括血脂、年龄、性别、高血压、糖尿病、慢性肾脏疾病以及吸烟,但其发生的细胞和分子机制仍未阐明[3-5].近年的研究表明,与动脉粥样硬化一样,动脉钙化是一种慢性炎症性疾病,具有炎症的所有特征：血管参与、渗出、炎性细胞浸润、细胞表型转换与死亡和组织增生[6-8].
作者 吉庆伟 周玉杰
机构地区 首都医科大学附属北京安贞医院 北京市心肺血管疾病研究所十二病房
出处 《心肺血管病杂志》 CAS 2015年第1期67-69,共3页 Journal of Cardiovascular and Pulmonary Diseases
关键词 动脉钙化 慢性炎症 心血管疾病 @@
分类号 R54 [医药卫生—心血管疾病]
  • 相关文献

参考文献30

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二级参考文献19

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共引文献97

同被引文献81

  • 1张磊.益赛普联合甲氨蝶呤治疗类风湿关节炎的作用机制[J].中国老年学杂志,2014,34(12):3338-3339. 被引量：13
  • 2寿涛,李芹,林俊,郑红梅,张虹,毕丹艳,梅坚,和芳,严新民.类风湿关节炎发生动脉粥样硬化的机制研究[J].中华风湿病学杂志,2006,10(9):558-560. 被引量：31
  • 3Ying-Li Lu,Lin Kuang,Hui Zhu,Hui Wu,Xue-Fang Wang,Yu-Ping Pang,Ning-Jian Wang,Dan-Lu Yu.Changes in aortic endothelium ultrastructure in male rats following castration, replacement with testosterone and administration of 50α-reductase inhibitor[J].Asian Journal of Andrology,2007,9(6):843-847. 被引量：14
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引证文献12

二级引证文献81

心肺血管病杂志
2015年 第1期

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