摘要
目的探讨冠心病病人血浆瘦素水平、踝臂指数(ABI)和脉搏波传导速度(PWV)与冠状动脉病变之间的关系。方法选取在青岛大学医学院附属医院心内科行冠状动脉造影的住院病人148例,其中诊断为急性冠状动脉综合征(ACS)64例,诊断为稳定型心绞痛(SAP)43例,冠状动脉造影正常者41例(NC组)。采用酶联免疫法检测血浆瘦素水平,动脉硬化检测仪检测ABI和PWV。结果 ACS组、SAP组血浆瘦素水平及PWV均明显高于NC组(F=26.82~235.70,P<0.05),ABI均明显低于NC组(F=11.05、17.62,P<0.05)。冠心病病人血浆瘦素水平高于NC组,其中三支及双支病变组血浆瘦素水平及PWV均明显高于NC组及单支病变组,而三支及双支病变组ABI则明显低于NC组及单支病变组(F=4.93~141.46,P<0.05)。冠心病病人血浆瘦素水平与ABI呈负相关(r=-0.676,P<0.01),与PWV呈正相关(r=0.707,P<0.01)。结论冠心病病人血浆瘦素水平明显升高,瘦素水平升高与冠状动脉狭窄程度及斑块的稳定性关系密切。瘦素可能是冠心病的一个新的独立危险因子。
Objective To investigate the correlation between levels of plasma leptin, ankle brachial index （ABI）, pulse wave velocity （PWV） and coronary heart disease （CHD）. Methods A total of 148 inpatients who underwent coronary arteriog- raphy in the Affiliated Hospital of Qingdao University Medical College were enrolled. Of whom, 64 were diagnosed as having acute coronary syndrome （ACS）, 43 having stable angina pectoris （SAP） and 41 served as normal controls （NC）. Plasma leptin was de- tected by ELISA and the ABI and PWV were tested by non-invasive vascular screening device. Results The levels of leptin and PWV in ACS and SAP groups were higher than the normal controls （F ： 26.82- 235.70：P 〈 0.05）, and ABI was lower （F 11.05,17.62 ;P〈0.05）. The leptin levels in CHD patients were higher than normal controls. Compared with the NC group and sin- gle-vessel-disease group, the leptin levels and PWV were higher in the triple-vessel-and double-vessel-disease group, ABI was lower in the t riple-vessel-and double-vessel-disease group （F = 4.93-- 141.46, P ~0.05）. The ABI was negatively correlated with leptin （r ^--0.676,P〈0.01） and PWV was positively correlated with leptin （r=0.707,P〈0.01） in patients wit CHD. Conclusion Plasma Leptin levels are significantly higher in patients with coronary heart disease. The elevation of leptin levels is closely related with the severity of coronary artery stenosis and the stability of the plaque. Leptin might be a new independent risk factor for coro- nary heart disease.
出处
《青岛大学医学院学报》
CAS
2015年第1期4-7,共4页
Acta Academiae Medicinae Qingdao Universitatis
