局部灌注给药辅助治疗糖尿病并发复治肺结核的观察

LOCAL INFUSION THERAPY FOR DIABETIC MELLITUS COMPLICATED WITH RETREATMENT PULMONARY TUBERCULOSIS

目的探讨局部灌注给药辅助治疗糖尿病并发复治肺结核的疗效及安全性。方法将96例糖尿病并发复治肺结核的病人随机分为治疗组（45例）和对照组（51例）。两组均给予异烟肼、利福平、乙胺丁醇、吡嗪酰胺、链霉素抗结核治疗3个月,之后异烟肼、利福平继续治疗9个月。治疗组在此基础上每周经支气管镜灌注异烟肼0.3g,共4~6次。比较两组病人治疗后痰液结核菌阴转率及疗效。结果治疗3个月后,治疗组痰液结核菌阴转率、疗效均优于对照组,差异有显著性（χ2=5.01、3.95,P〈0.05）。结论局部灌注给药辅助治疗糖尿病并发复治肺结核安全有效。

Objective To assess the efficacy and safety of local infusion therapy （LIT） for diabetes complicated with re- treatment pulmonary tuberculosis （RPT）. Methods Ninety-six diabetic patients with RPT were randomized to treatment group （n = 45） and control group （n = 51）. The patients in both groups were given isoniazid, rifampin, ethambutol, pyrazinamide, and streptomycin for three months, and then iosniazid and rifampin continued for nine months. The patients in the treatment group were offered transbronchial instillation of 0.3 g isoniazid, once a week for 4--6 times, in addition to the above mentioned therapy. The negative rate of TB in sputum and efficacy were compared between the two groups. Results After three months of the treatment, the negative rate of TB in sputum was higher and the effectiveness was better in the treatment group versus the control one, the difference between the two groups being significant （Z2 =5.01,3.95;P〈0.05）. Conclusion Local infusion therapy for diabetic patients with retreatment pulmonary tuberculosis is safe and effective.