期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

补体激活与重度子痫前期发病的关系 被引量：5

CORRELATION BETWEEN COMPLEMENT ACTIVATION AND PATHOGENESIS OF SEVERE PREECLAMPSIA
下载PDF
导出
摘要 目的检测重度子痫前期孕妇血清中补体C3a、C5a及血管紧张素Ⅱ1型受体自身抗体（AT1-AA）水平变化,从而探讨补体激活与重度子痫前期发病的相关性。方法选取重度子痫前期孕妇30例,正常孕妇30例作为对照,采用ELISA法检测两组血清中C3a、C5a及AT1-AA的表达水平,并分析C3a、C5a与AT1-AA的相关性。结果重度子痫前期孕妇血清中C3a、C5a、AT1-AA水平明显高于对照组（t=2.582~4.681,P〈0.05）;重度子痫前期孕妇血清中C3a、C5a与AT1-AA水平呈正相关（r=0.283、0.543,P〈0.05）。结论孕妇体内补体C3a、C5a激活可能造成AT1-AA生成增加,并参与重度子痫前期的发病过程。 Objective To investigate the correlation between complement activation and the pathogenesis of severe pre- eclampsia by detecting levels of serum C3a, C5a and angiotensin Ⅲ receptor subtype 1 autoantibody （ATlhAA） in pregnant women. Methods Thirty cases of severe preeclampsia, and 30 of normal pregnant women were enrolled in this study. The levels of serum C3a, CSa, and ATI：-AA were detected by ELISA, the correlation between C3a, C5a and AT1-AA were analyzed. Results Serum levels of C3a, C5a and AT1-AA in the severe preeclampsia were significantly higher than the normal pregnant women （t= 2.582-4.681 ,P〈0.05）. The serum levels of C3a and C5a were positively correlated with AT1-AA in the severe preeclampsia （r=0.283, 0.543;P〈0.05）. Conclusion Activation of C3a and C5a in the body of pregnant women may increase the production of AT1-AA and involve in the process of development of severe preeclampsia.
作者 孔予杰 王大伟 隋爱华 张宁 叶元华
机构地区 青岛大学医学院附属医院产科
出处 《青岛大学医学院学报》 CAS 2015年第1期99-101,共3页 Acta Academiae Medicinae Qingdao Universitatis
关键词 补体C3a 补体C5A 血管紧张素Ⅱ 自身抗体 子痫前期 complement C3a complement CSa angiotensin Ⅲ antibodies preeclampsia
分类号 R714.245 [医药卫生—妇产科学]
  • 相关文献

参考文献19

  • 1SACKS S H. Complement fragments C3a and C5a: the salt and pepper of the immune response[J]. Eur J Immunol, 2010, 40(3):668-67G.
  • 2COCHRANE C G, MULLER-EBERHARD H J. The deriva- tion of two distinct anaphylatoxin activities from the third and fifth components of human complement[J]. J Exp Med, 1968,127(2)371-386.
  • 3HARTMANN K, HENZ B M, KRUGER-KRASAGAKES S, eta[. C3a and C5a stimulate ehemotaxis of human mast cells J-J. Blood, 1997,89(8) :2863-2870.
  • 4WALLUKAT G, HOMUTH V, FISCHER T, et al. Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor[J]. Journal of Clinical Investigation, 1999,103 (7) : 945-952.
  • 5WANG W, IRANI R A, ZHANG Y, et al. Autoantibody-me- diated complement C3a receptor activation contributes to the pathogenesis of preeclampsia[J]. Hypertension, 2012,60 (3) : 712-721.
  • 6LYNCH A M, ECKEL R H, MURPHY J R, et al. Prepreg- nancy obesity and complement system activation in early preg- nancy and the subsequent development of preeclampsia[J]. Am ]Obstet Gyneeo[, 2012,206(428) : el-eS.
  • 7SOTO E, ROMERO R, RICHANI K, et al. Preeclampsia and pregnancies with small-for-gestational age neonates have dif- ferent profiles of complement split products[J]. Journal of Ma- ternal-Fetal and Neonatal Medicine, 2010,23 (7) : 646-657.
  • 8LAPPAS M. Lower circulating levels of complement split pro- teins C3a and C4a in maternal plasma of women with gesta- tional diabetes mellitus[J]. Diabetic Medicine, 2011,28 (8) : 906-911.
  • 9KOHLER P F. Maturation of the human complement system. I. Onset time and sites of fetal Clq, C4, C3, and C5 synthe- sis[J]. Journal of Clinical Investigation,1973,52(3):671.
  • 10QING X, REDECHA P B, BURMEISTER M A, et al. Tar- geted inhibition of complement activation prevents features of preeclampsia in miee[J]. Kidney Int, 2011,79(3):331-339.

二级参考文献15

  • 1SEVAL Y,SATI L,CELIK-OZENCI C,et al.The distribution of angiopoietin-1,angiopoietin-2 and their receptors Tie-1 and Tie-2 in the very early hman placenta[J].Placenta,2008,29(9):809-815.
  • 2YANCOPOULOS G D,DAVIS S,GALE N W,et al.Vascular-specific growth factora and blood vessel formation[J].Nature,2000,407(6801):242-248.
  • 3WITZENBICHLER B,MAISONPIERRE P C,JONES P,et al.Chemotactic properties of angiopoietin-1 and -2,ligands for the endothelial-specific receptor tyrosine kinase Tie2[J].J Biol Chem,1998,273(29):18514-18521.
  • 4MAISONPIERRE P C,SURIC C,JONES P F,et al.Angiopoietin-2,a natural antagonist for Tie2 that disrupts in vivo angiogenesis[J].Science,1997,277(5322):55-60.
  • 5NADAR S K,KARALIS L,YEMENI E A,et al.Plasma arkers of angiogenesis in pregnancy induced hypertension[J].Thromb Haemost,2005,94(5):1071-1076.
  • 6HIROKOSHI K,MAESHIMA Y,KOBAYASHI K,et al.Increase of serum angiopoietin-2 during pregnancy is suppressed in women with preeclampsia[J].Am J Hypertents,2005,18(9Pt1):1181-1188.
  • 7HIROKOSHI K,MAESHIMA Y,KOBAYASHI K,et al.Elevated serum sFlt-1/Ang-2 ratio in women with preeclampsia[J].Nephron Clin Pract,2007,106(1):43-50.
  • 8ZHANG E G,SMITH S K,BAKER P N,et al.The regulation and localization of angiopoietin-1,-2,and their receptor Tie2 in normal and pathologic human placentae[J].Mol Med,2001,7(9):624-635.
  • 9LEACH L,AABAWALE M O,ANDERSON M,et al.Vasculogenesis,angiogenesis and the molecular organisation of endothelial junction in the early human placenta[J].J Vasc Res,2002,39(3):246-259.
  • 10WULFF C,WILSON H,DICKSON S E,et al.Hemochorial placentation in the primate:expression of vascular endothelial growth factor,angiopoietins,and their receptors throughout pregnancy[J].2002,66(3):802-812.

共引文献5

同被引文献30

  • 1SAITO S, NAKASHIMA A, SHIMA T, et al. Thl/Th2/ Thl7 and regulatory T-cell paradigm in pregnancy[J]. Am JReprod Immunol, 2010,63(6) : 601-610.
  • 2LAU S Y, GUILD S J, BARRETT C J, et al. Tumor necrosis factor-alpha, interleukin-6, and interleukin-10 levels are al- tered in preeclampsia: a systematic review and meta-analysis [J]. Am J Reprod Immunol, 2013,70(5) :412-427.
  • 3KALINDERIS M, PAPANIKOLAOU A, KALINDERI K, et al. Elevated serum levels of interleukin-6, interleukin-l[? and human ehorionic gonadotropin in preeclampsia[J]. Am J Re- prod Immunol, 2011,66(6) :468-475.
  • 4ZHANG Z, GAO Y, ZHANG L, et al. Alterations of IL-6, IL-6R and gp130 in early and late onset severe preeclampsia :-J:. Hypertens Pregnancy, 2013,32(3) :270-280.
  • 5LUO J Y, ZHONG Y, CAO J C, et al. Efficacy of oral colon- specific delivery capsule o{ low-molecular-weight heparin on ul- cerative colitisFJ:.Biomed Pharmacother, 2011,65(2) : 111.
  • 6LEE J H, KIM C H, SEO G H, et al. Heparin attenuates the ex- pression of TNFalpha-induced cerebral endothelial cell adhesion molecule[J]. Korean J Physiol Pharmacol, 2008,12(5) :231 236.
  • 7XIE F, HU Y, TURVEY S, et al. Toll-like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre- eclampsia[J]. BJOG, 2010,117 : 99-108.
  • 8STEEGERS E A, VON DADELSZEN P, DUVEKOT J J, et al. Preeclampsia[J]. Lancet, 2010,376 .. 631 -644.
  • 9DEKKER G A, SIBAI B M. Etiology and pathogenesis of pree- clampsia= current conceptsT-J. Am J Obstet Gynecol, 1998, 1791-1359 1375.
  • 10LACHMEIJER A, DEKKER G A, PALS G, et al. Searching for preeclampsia genes: the current position[J]. European Journal of Obstetrics Gynecology and Reproductive Biology, 2002,105(2) : 94-113.

引证文献5

二级引证文献17

青岛大学医学院学报
2015年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部