米索前列醇联合哌替啶及异丙嗪用于生育前无痛人工流产效果

MISOPROSTOL IN COMBINATION WITH MEPERIDINE AND PROMETHAZIE FOR PAINLESS ARTIFICIAL ABORTION

目的探讨米索前列醇并哌替啶、异丙嗪用于无痛人工流产的临床效果。方法选择2008年12月—2011年12月行人工流产终止妊娠者1 940例,分为实验组及3个对照组,实验组800例,术前2h口服米索前列醇600μg,术前经静脉缓慢注射哌替啶75 mg,异丙嗪25 mg;对照1组680例,术前经静脉缓慢注射哌替啶75mg,异丙嗪25mg;对照2组260例,术前2h口服米索前列醇600μg;对照3组200例,术前及术中不应用任何药物,常规行人工流产手术。比较各组病人疼痛程度、失血量、人工流产综合征发生率、宫颈扩张及手术时间等情况。结果实验组镇痛效果、人工流产综合征的发生率、手术时间及阴道出血量与各对照组相比差异有显著性(χ2=936.061、59.886,F=1 247.409、38.656,P<0.01)。结论米索前列醇并哌替啶、异丙嗪在人工流产术中镇痛效果肯定,此方法应用方便,安全有效,经济实用,值得在基层医院推广应用。

Objective To assess the efficacy of Misoprostol combined with Demerol and Promethazine in painless artifi cial abortion. Methods This study consisted of 1 940 women who underwent an artificial abortion for termination of pregnancy （from December 2008 to December 2011） who were divided into an experimental group and three control groups. The 800 patients in experimental group were given oral Misoprostol 600μg, and Ⅳ Demerol 75 mg plus Promethazine 25 mg were offered 2 h before the procedures. For 680 cases in control group 1, Ⅳ Demerol 75 mg plus Promethazine 25 mg were given before the operation; For 260 cases in control group 2, oral Misoprostol 600 μg was given 2 hours before operation; for 200 cases in control group 3, no medications were offered before and at the operation. A comparison was conducted among the each group in terms of the following items： the degree of pain, blood loss, the incidence of abortion syndrome, the time of cervical dilation and operation time. Results The differences among the experimental group and each control group were significant with regard to analgesic effect, the incidence of abortion syndrome, operation time and vaginal bleeding （ x^2 = 936. 061,59. 886 ： F = 1 247. 409,38.656 ; P 〈 0.01 ）. Conclusion The analgesic effect is certain by using combination of Demerol, Promethazine and Misoprostol for artificial abortion, which is convenient, safe, economic and practical, and worth promotion and application in primary hospitals.