参附注射液对恶性肿瘤化疗患者血小板的影响

Effects of Shenfu Injection on Platelet in Patients with Malignant Tumor

目的观察参附注射液对恶性肿瘤化疗患者血小板的影响。方法选择2013年1月~2014年5月我院确诊为恶性肿瘤并且满足化疗条件的83例患者,随机分为A治疗组42例（参附注射液＋常规方案化疗）和B对照组41例（0.9%NS＋常规方案化疗）。将同期常规化疗后血小板数低于正常值的90例恶性肿瘤患者随机分为C治疗组45例（参附注射液）和D对照组45例（0.9%NS）。以上四组治疗开始后每周复查血常规比较两组间PLT计数,A、B组化疗2周期后评价两组血小板受抑制状况,C、D组治疗2周后评价两组血小板恢复状况。结果 A、B两组化疗有效率相仿,但A治疗组血小板抑制发生5例,明显低于B对照组12例;C、D两组血小板值较治疗前均有所恢复,C治疗组血小板达正常值38例,D对照组血小板达正常值14例。结论参附注射液能明显改善恶性肿瘤化疗患者血小板抑制。

Objective To observe the effect of Shenfu Injection on platelet in patients with malignant tumor. Meth- ods 83 cases of choice in 2013 January - 2014 year in May in our hospital diagnosed as malignant tumor chemotherapy and meet the conditions of the patients were randomly divided into A treatment group 42 cases （ Shenfu Injection plus rou- tine chemotherapy） and B in 41 cases of the control group （routine 0.9 % NS＋ regimen）. The routine chemotherapy platelet count below the normal value of 90 eases of malignant tumor were randomly divided into C treatment group 45 ca- ses （Shenfu Injection） and D in 45 cases of the control group （0.9 % NS）. Started more than four groups after treatment were compared between the two groups of weekly review the blood PLT counting, A, B group of 2 cycles of chemotherapy after the evaluation of two groups platelet inhibition condition, C, D group after 2 weeks of treatment, two groups of plate- let recovery status evaluation. Results A, B two groups of effective chemotherapy rate was similar, but A treatment group platelet inhibition occurred in 5 cases, 12 cases of control group were significantly lower than that of B; C, D two groups platelet values than before treatment was restored by C treatment group platelet reached the normal level in 38 cases, Dgroup 14 patients reached normal values of platelet. Conclusion Shenfu injection can significantly improve the inhibition of platelet in patients with malignant tumor chemotherapy.