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晚期平滑肌肉瘤的二线化疗 被引量：4

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摘要 平滑肌肉瘤(leiomyosarcoma,LMS)是一种侵袭性的软组织肉瘤,目前多采用以手术切除为主的综合治疗方案。对于晚期尤其是转移性LMS患者,主要的治疗手段为系统化疗和分子靶向治疗。综合近年的研究结果,对于一线治疗失败的LMS患者,二线单药化疗可以选用吉西他滨(GEM)、达卡巴嗪(DTIC)和替莫唑胺(TMZ),联合化疗可以选用GEM联合多西他赛(TXT)或DTIC等方案。对于二线化疗失败、有化疗禁忌证或拒绝化疗者,可以尝试使用帕唑帕尼等分子靶向药物。
作者 孙元珏 姚阳
机构地区 上海交通大学附属第六人民医院肿瘤内科
出处 《癌症进展》 2015年第1期19-23,共5页 Oncology Progress
关键词 平滑肌肉瘤 内科治疗
分类号 R730.5 [医药卫生—肿瘤]
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参考文献23

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同被引文献56

  • 1彭惠,杨光华,步宏,郭立新,王华.软组织平滑肌肉瘤3p微卫星不稳定性及其临床意义[J].临床与实验病理学杂志,2004,20(3):277-280. 被引量：1
  • 2韦敏,肖亿.替莫唑胺的临床应用进展[J].现代医药卫生,2006,22(12):1825-1826. 被引量：1
  • 3黄文权,潘恒,李冲云.少见部位平滑肌肉瘤的CT诊断（附12例分析）[J].中国医学影像学杂志,1996,4(2):109-110. 被引量：1
  • 4Vraa S, Keller J, Nielsen OS, et al. Prognostic factors in soft tissue sar- comas: the Aarhus experience. Eur J Cancer, 1998,34:1876-1882.
  • 5Kfstler WJ, Brodowicz T, Attems Y, et al. Docetaxel as rescue medication in anthracycline- and ifosfamide-resistant locally advanced or metastatic soft tissue sarcoma: results of a phase II triall. Ann Oncol,2001,12: 1281-1288.
  • 6look KY, Sandier A, Blessing JA, et al. Phase lI trial of gemcitabine as second-I ine chemotherapy of uterine eiomyosarcoma: a Gynecologic On- cology Group (GOG) Study. Gynecol Oncol,2004,92:644-647.
  • 7Hensley ML, Maki R, Venkatraman E, et al. Gemcitabine and docetax- el in patients with unresectable leiomyosarcoma: results of a phase II tri- al. J Clin Oncol, 2002, 20:2824-2831.
  • 8Leu KM, Ostnlszka LJ, Shewach D, et al. Laboratory and clinicalevi- dence of synergistic cytotoxicity of sequential treatment with gemcitabine followed by docetaxel in the treatment of sarcoma. J Clin Oncol, 2004, 22 : 1706-1712.
  • 9Maki RG, Wathen JK, Patel SR, et al. Randomized phase II study of gemcitabine and doeetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: results of sarcoma alliance for research through collaboration study 002. J Clin Oncol, 2007, 25: 2755-2763.
  • 10Bay JO, Ray-Coquard I, Fayette J, et al. Docetaxel and gemcitabine combination in 133 advanced soft-tissue sarcomas: a retrospective analy- sis. Int J Cancer, 2006, 119: 706-711.

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癌症进展
2015年 第1期

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