融合蛋白药物的研究进展

Research progress of fusion protein drugs

融合蛋白药物是利用基因工程技术将不同的基因或基因片段融合在一起,经表达后可以得到由不同的功能蛋白拼合在一起而形成的新型多结构域的人工蛋白,可以优化蛋白性能,甚至产生新功能,是一种极具潜在应用价值与理论意义的方法。目前用这种方法形成的许多融合蛋白药物已经研制成功并应用于临床治疗,该文尝试对融合蛋白药物分类及对各类的发展情况进行综述。

Fusion protein drugs are prepared by fusing different genes or gene fragments by genetic engi- neering, and thus producing the artificial protein after expressing, which has become new functional proteins with mixed multiple different domains. This way can optimize performance or even makes protein having new function. It extremely has potential applications and theoretical significance. At present, many fusion protein drugs have devel- oped and applied in clinical treatment. In this paper, the development and classification of fusion protein drugs were reviewed.