内皮祖细胞在动脉粥样硬化临床中的应用

Clinical application of endothelial progenitor cells in atherosclerosis

内皮祖细胞(EPCs)是一种成血管干细胞,通过刺激诱导能够增殖分化为成熟血管内皮细胞的前体细胞,参与血管内皮细胞的损伤和修复。动脉粥样硬化(AS)是血管内皮损伤和脂质聚集在动脉壁上形成的血管病变。机体可通过动员体内EPCs来修复血管内皮细胞从而达到缓解,治疗AS的目的。EPCs对血管内皮细胞修复的作用近年来被广泛研究,本文就内皮祖细胞对AS治疗中的应用以及其基础研究进行系统的综述。

Endothelial progenitor cells（EPCs） is an angiogenic stem cells can induce proliferation by stimulating precursor cells differentiate into mature endothelial cells involved in endothelial cell injury and repair. Atherosclerosis（AS） is a vascular endothelial injury and lipid accumulation in the artery walls forming blood vessels. Mobilization of EPCs in vivo by the body to repair the endothelial cells so as to achieve mitigation, treatment, AS purposes. EPCs repair of vascular endothelial cells has been extensively studied in recent years, in this paper, application of progenitor cells in the treatment of atherosclerosis and its basic researches were systematically reviewed.