Brugada综合征研究现状

Research Status and Progress on the Brugada Syndrome

Brugada综合征(Brugada syndrome,Br S)是一种遗传性心律失常病,多以晕厥和猝死为首发症状。1992年Brugada兄弟首次报道后,一直是心血管病基础和临床研究的热点。Br S诊断包括心电图Brugada波和典型临床表现。目前,唯一被证明能有效预防Br S患者发生猝死的措施是埋藏式心脏转复心脏复律除颤器,药物治疗仍首选奎尼丁。本文就Br S病理生理机制、临床心电图表现、诊断及危险分层及治疗最新研究进展作一综述。

The Brugada syndrome（ Br S） is a kind of inherited cardiac arrhythmia,usually starting with such symptoms as syncope and sudden death. It was initially reported in 1992 by Pedro and Josep Brugada,and has always been a popular issue in the basic and clinical research of cardiovascular disease. The Br S diagnosis includes ECG Brugada wave and typical clinical symptoms. Presently,the only effective measure to prevent Br S patients from sudden death is the implantable cardioverter defibrillator（ ICD）,and quinidine is the first choice in drug treatment. This paper reviewed the Br S pathophysiological mechanisms,clinical ECG manifestation,diagnosis,risk stratification and the latest research progress in its treatment.