低分子肝素对子痫前期患者凝血功能的影响

The impact of low molecular weight heparin on coagulation function in patients with preeclampsia

目的探讨低分子肝素对子痫前期患者凝血功能的影响。方法选取2013年1月~2014年8月在本院就诊的子痫前期患者80例作为研究组,在常规治疗的同时给予小剂量低分子肝素,选择同期子痫前期患者60例作为对照组,给予常规治疗。比较两组凝血功能相关指标的变化及产后出血量。结果研究组的PT、APTT、TT长于对照组,D2聚体、纤维蛋白原水平明显低于对照组,差异均有统计学意义（P〈0.05）,两组的PLT、产后出血量差异无统计学意义（P〉0.05）。结论低分子肝素可以明显改善子痫前期患者的高凝状态,不增加出血风险。

Objective To investigate the impact of low molecular weight heparin（LMWH） on coagulation function in patients with preeclampsia. Methods 80 patients with preeclampsia treated in our hospital from January 2013 to August2014 were selected as the study group,and they were given the conventional treatment and small dose LMWH,at the same time,60 cases with preeclampsia were choosed as the control group,and they were given the conventional treatment. Change of coagulation function indicators and postpartum hemorrhage volume were compared between the two groups. Results Prothrombin time（PT）,activated partial thromboplastin time（APTT）,thrombin time（TT） in the study was longer than that in the control group respectively,level of D-dimer,fibrinogen（FIB） in the study was lower than that in the control group respectively（P〈0.05）.There were no statistical difference of platelet（PLT） and postpartum hemorrhage between the two groups（P〉0.05）. Conclusion LMWH can obviously improve the high coagulation state of preeclampsia patients,and it dose not increase the risk of bleeding.