喹硫平联合丙戊酸钠治疗双相障碍躁狂的临床效果

Clinical effect of quetiapine combined with sodium valproate in the treatment of bipolar disorder manic

目的观察喹硫平联合丙戊酸钠治疗双相障碍躁狂的有效性及安全性。方法选取本院2012年3月~2014年3月收治的80例双相障碍躁狂患者,将其随机分成研究组和对照组,各40例。对照组给予喹硫平治疗,研究组给予喹硫平联合丙戊酸钠治疗,连续治疗8周。采用Bech-Rafaelsen躁狂量表（BRMS）评估治疗效果,比较两组的总有效率、不良反应发生率。结果治疗后4、8周,研究组的BRMS评分明显低于对照组,差异有统计学意义（P〈0.05）;治疗后8周,两组的总有效率比较,差异无统计学意义（P〉0.05）;两组的不良反应发生率比较,差异有统计学意义（P〈0.05）。结论喹硫平联合丙戊酸钠对双相障碍躁狂的效果确切,安全可靠,值得临床推广应用。

Objective To observe the effectiveness and safety of quetiapine combined with sodium valproate in the treatment of bipolar disorder manic. Methods From March 2012 to March 2014,80 patients with bipolar disorder manic treated in our hospital were selected and randomly divided into the research group（n=40） and control group（n=40）.The control group was given quetiapined,while the research group was given quetiapine combined with sodium valproate.The course of treatment lasted 8 weeks.The therapeutic effect was evaluated by Bech-Rafaelsen mania scale（BRMS）.The total effective rate,the incidence rate of adverse reaction in the two groups were compared. Results After 4,8 weeks treatment,BRMS score of the research group was greatly lower than that in the control group with a statistical difference（P〈0.05）. After 8 weeks treatment,there was no statistical difference of the total effective rate in the two groups（P〉0.05）. There was a statistical difference of the incidence rate of adverse reaction in the two groups（P〈0.05）.Conclusion Quetiapine combined with sodium valproate in the treatment of bipolar disorder manic obtains a definite therapeutic effect.It is safe and reliable,and is worthy of clinical expansion and application.