厄贝沙坦联合左旋氨氯地平治疗高血压并发慢性肾功能不全的临床观察

Clinical observation of irbesartan combined with levamlodipine Levamlodipine treating hypertension complicated with chronic renal insufficiency

目的观察厄贝沙坦联合左旋氨氯地平治疗高血压并发慢性肾功能不全的临床效果。方法将患者随机分为治疗组、对照组,治疗组服用厄贝沙坦联合左旋氨氯地平,对照组服用左旋氨氯地平,共治疗12周。定期检测患者的血压、血清钾、血尿酸、肝肾功能。结果两组治疗12周后的血压均明显下降(P<0.01),两组治疗后的收缩压差异有统计学意义(P<0.05),舒张压差异无统计学意义(P>0.05)。治疗组治疗后的尿蛋白明显下降(P<0.01),血尿酸也有所下降(P<0.05),与对照组比较,差异有统计学意义(P<0.05),其他生化指标无明显变化。结论厄贝沙坦联合左旋氨氯地平的效果好,副作用少,且对患者的肾功能有保护作用,是治疗慢性肾功能不全的理想药物。

Objective To observe the clinical effect of irbesartan combined with levamlodipine treating hypertension complicated with chronic renal insufficiency. Methods Patients were randomly divided into the treatment group and control group,the treatment group was treated with irbesartan combined with levamlodipine, and the control group was only given levamlodipine.Patients were treated for 12 weeks.Blood pressure,serum potassium,serum uric acid,liver and kidney function of patients were detected regularly. Results The blood pressure of the two groups after 12 weeks treatmerit decreased significantly （P〈0.01）,and there was a statistical difference of the systolic blood pressure between the two groups （P〈0.05）,there was no statistical difference of diastolic blood pressure between the two groups （P〉0.05）.Compared with the control group,the urinary protein of the treatment group significantly decreased （P〈0.01）,blood uric acid also decreased （P〈0.05）,there was no obvious changes in other biochemical indexes. Conclusion Irbesartan combined with levamlodipine has a good effect with fewer side effects,and has protective role on renal function.Irbesartan combined with levamlodipine are idea drug treating chronic renal insufficiency.