摘要
目的探讨乙型肝炎疫苗联合乙型肝炎免疫球蛋白(HBIG)阻断乙型肝炎病毒(HBV)母婴传播的效果。方法选择2009年1月~2011年6月本院妇产科收治的116例乙型肝炎表面抗原(HBs Ag)阳性的乙型肝炎产妇以及已按照免疫程序注射过HBIG以及乙型肝炎疫苗的年龄为1岁的婴儿作为研究对象,采用自制调查问卷对产妇进行乙型肝炎防治知识调查,检测婴儿血清HBs Ag。结果 HBs Ag阳性产妇对于乙型肝炎能够通过母婴传播的知晓率较高,认为乙型肝炎疫苗和HBIG可以预防乙型肝炎母婴传播者所占比例为74.14%。受检婴幼儿中,HBs Ag检测阳性11例(9.48%),阻断成功率为90.52%。母亲为乙肝大、小三阳所生的婴儿HBs Ag阳性率分别为14.71%和2.08%,两者比较差异有统计学意义(P〈0.05);母亲孕期接种和未接种HBIG的婴儿HBs Ag阳性率分别为6.58%和15.00%,剖腹产以及顺产的婴儿HBs Ag阳性率分别为13.51%和7.59%,人工喂养和母乳喂养的婴儿HBs Ag阳性率分别为9.09%和8.54%,以上观察指标比较差异均无统计学意义(P〉0.05)。结论加强HBV感染孕妇的乙型肝炎防治知识健康宣教,并按照免疫程序对新生儿联合接种乙型肝炎疫苗和HBIG,可以有效降低乙型肝炎的母婴传播率。
Objective To observe the effect of hepatitis B vaccine combined with hepatitis B immunoglobulin(HBIG) to block mother-to-fetus of hepatitis B virus(HBV). Methods 116 pregnant women of positive hepatitis B surface antigen(HBs Ag) and infant injected HBIG and hepatitis B vaccine at the age of 1 years according to the immunization program from January 2009 to June 2011 in our hospital were selected as the research object.The questionnaire investigation of hepatitis B prevention knowledge on maternal was used and infant serum HBs Ag was detected. Results The rate of mother-to-fetus of hepatitis B virus in pregnant women of HBs Ag positive was higher.There was 74.14% of the people thought that the hepatitis B vaccine and HBIG could prevent mother to child transmission of hepatitis B.The infants tested HBs Ag positive in 11 cases,the positive rate of HBs Ag was 9.48%,blocking the success rate was 90.52%.The positive rate of babies with mother were 14.71% and 2.08%,there was significant difference between the two groups(P〈0.05).The positive rate of maternal infant HBs Ag inoculated and non inoculated HBIG was 6.58% and 15%.The positive rate of babies with cesarean section and vaginal delivery was 13.51% and 7.59%.The positive rate of HBs Ag of artificial feeding and breast-feeding infants was 9.09% and 8.54%,the above observation indexes of two groups was not significant(P〉0.05). Conclusion To strengthen prevention and control of hepatitis B knowledge health education of pregnant women infected with HBV,and in accordance with the immunization program on neonatal joint vaccination of hepatitis B vaccine and HBIG,can effectively reduce the rate of mother-to-fetus transmission of hepatitis B.
出处
《中国当代医药》
2015年第3期183-185,共3页
China Modern Medicine
关键词
乙型肝炎防治知识
乙型肝炎疫苗
乙型肝炎免疫球蛋白
乙型肝炎
母婴传播
Knowledge of hepatitis B prevention
Hepatitis B vaccine
Hepatitis B immunoglobulin
Hepatitis B
Mother-to-fetus transmission