阿奇霉素序贯疗法治疗小儿支原体肺炎的效果

Effect of azithromycin sequential therapy in the treatment of children with Mycoplasma pneumonia

目的探讨阿奇霉素序贯疗法治疗小儿支原体肺炎的临床效果。方法选取本院2012年2月~2014年3月收治的支原体肺炎患儿215例,将其随机分为观察组（107例）和对照组（108例）,对照组采用红霉素序贯疗法治疗,观察组采用阿奇霉素序贯疗法。比较两组的临床疗效及不良反应情况。结果观察组总有效率为94.4%,高于对照组的75.9%,差异有统计学意义（χ2=14.468,P〈0.01）。观察组退热、咳嗽消失、啰音消失、呕吐消失时间及住院时间均明显短于对照组,差异有统计学意义（P〈0.05）。观察组恶心、呕吐、泄泻等胃肠道反应,皮疹,ALT升高的发生率明显低于对照组,差异有统计学意义（P〈0.05）。结论阿奇霉素序贯疗法治疗小儿支原体肺炎效果显著,可缩短治疗时间,减少不良反应的发生,效果优于红霉素,可成为治疗小儿支原体肺炎的首选疗法,具有临床推广意义。

Objective To explore the efficacy of azithromycin sequential therapy in the treatment of children with Mycoplasma pneumonia. Methods 215 children with Mycoplasma pneumonia treated in our hospital from February 2012 to March 2014 were selected,and were randomly divided into observation group（107 cases） and control group（108 cases）,control group were given with erythromycin sequential therapy,observation group were treated with azithromycin sequential therapy.The clinical efficacy and adverse reactions of two groups was compared. Results The t otal effective rate of observation group was 94.4%,higher than 75.9% of control group,the difference was significant（χ2=14.468,P〈0.01）.The time of fever,cough disappeared,rales disappeared,vomiting disappeared and length of stay hospital in observation group was shorter than that in control group,the difference was significant（P〈0.05）.The incidence of gastrointestinal reaction,including nausea,vomiting,diarrhea etc.,rash and ALT increasing in observation group was lower than that in control group,the difference was significant（P〈0.05）. Conclusion The curative effect of azithromycin sequential therapy is significant,can shorten the treatment time,reduce the adverse reactions,its efficacy is better than erythromycin,therefore become the preferred therapy in treatment of Mycoplasma pneumonia in children,has clinical promotion.