急性心肌梗死溶栓治疗后同型半胱氨酸水平的变化

Change of homocysteine level on acute myocardial infarction after thrombolytic therapy

目的探讨急性心肌梗死溶栓治疗后同型半胱氨酸水平的变化。方法回顾性分析2012年4月~2014年7月在本院治疗的46例急性心肌梗死患者的临床资料,应用酶联免疫吸附法对患者治疗前后的同型半胱氨酸水平进行检测,并与同期健康对照组对比。结果治疗前,实验组的血清同型半胱氨酸水平高于治疗后及对照组,差异均有统计学意义（P〈0.05）;治疗后,实验组的血清同型半胱氨酸水平与对照组比较差异无统计学意义（P〉0.05）。结论检测急性心肌梗死患者同型半胱氨酸水平,可了解患者的病情变化,其可作为评价预后的重要指标,值得临床推广应用。

Objective To explore change of homocysteine level on acute myocardial infarction （AMI）after thrombolytic therapy. Methods Clinical data of 46 patients with AMI treated in our hospital from April 2012 to July 2014 were ret-rospectively analyzed.Enzyme linked immunosorbent assay was applied to test the level of homocysteine before and after treatment,and the outcome was compared with that in the healthy control group at the same period. Results The level of serum homocysteine before treatment in experimental group was higher than that after treatment and in control group respectively,with statistical difference（P〈0.05）.After therapy,there was no statistical difference of serum homocys-teine in experimental group compared with control group （P〉0.05）. Conclusion Testing the homocysteine level in AMI patient in order to understand the disease condition can be considered as an important index to evaluate the prognosis, which is worthy of clinical expansion and application.