降钙素原与超敏C-反应蛋白检测在社区发热门诊中的应用

Application on detection of procalcitonin and high sensitivity C-reactive protein in community fever clinic

目的探讨降钙素原（PCT）与超敏C-反应蛋白（hs-CRP）检测在社区医院发热门诊中的应用价值。方法回顾性分析本院2014年1~10月130例发热且已进行病原学检查确诊患者资料,将患者分为细菌感染组和非细菌感染组,比较两组血清PCT和hs-CRP水平。结果细菌感染组的血清PCT和hs-CRP水平及阳性率均高于非细菌感染组,差异有统计学意义（P〈0.05）。PCT诊断细菌感染的敏感度、特异度均高于hs-CRP。结论血清PCT和hs-CRP水平在细菌感染所致发热中显著升高,两者检测均可用于发热门诊患者的病因学诊断,但PCT敏感度及特异度均优于hs-CRP。

Objective To investigate application on detection of procalcitonin（PCT）and high sensitivity C-reactive protein（hs-CRP）in community fever clinic. Methods Data of 130 patients with fever,diagnosed and received pathologic examination from January to October 2014 were retrospectively analyzed.All the cases were divided into the bacterial infection group and the non-bacterial infection group,and then the level of PCT and hs-CRP in two groups were compared. Results The level,positive rate of PCT and hs-CRP in bacterial infection group was higher than that in non-bacterial infection group respectively,with statistical difference（P〈0.05）.The sensitivity and specificity of PCT detection was better than that of hs-CRP respectively. Conclusion The level of PCT and hs-CRP of bacterial infection fever patients elevate significantly,the detection of both can be applied to the etiologic diagnosis of fever clinical patients,meanwhile,the sensitivity and specificity of PCT detection are better than that of hs-CRP detection.