度罗西汀联合喹硫平治疗躯体形式障碍的疗效研究

目的：比较分析度罗西汀联合喹硫平治疗躯体形式障碍的疗效及不良反应。方法：选择2011年6月~2014年10月我院就诊的63名躯体形式障碍患者,随机分为两组,研究组以度罗西汀联合喹硫平进行治疗,对照组单用度罗西汀治疗,疗程均为8周。治疗前与治疗后第2周、4周、8周分别采用汉密尔顿焦虑量表（HAMA）评定患者的焦虑及躯体性焦虑情况;并在第2周、第8周采用抗抑郁药不良反应评定量表（SERS）评定不良反应。结果：治疗后两组HAMA总分及躯体性焦虑因子评分均显著降低,差异显著（P〈0.05）,联合应用喹硫平组下降更为明显,治愈率高于单用度罗西汀组（16.7%,41.4%）,两组间差异有统计学意义（P〈0.05）。且联合应用喹硫平组在治疗2周后起效快于单用度罗西汀组,差异显著（P〈0.05）。两组间不良反应均表现较轻,大多出现在治疗早期,经对症治疗逐渐缓解。结论：度罗西汀联合喹硫平治疗躯体形式障碍较单用度罗西汀组疗效显著,起效快,且不良反应发生率低。

Objietive：To study the effect and Adverse reactions of Duloxetine augmented with Quetiapine in the treatment of？. somatoform disorder.Methods： Respectively using Hamilton anxiety scale and the scale for assessment of antidepressant drug adverse reactions, analysis of 63 somatoform disorde patients who clinic in our hospital during 2011.06-2014.10. The patients Were randomly divided into Duloxetine group, Duloxetine augmented with Quetiapine group, a course of 8 weeks. Assessed of the curative effect through the change of patients＇ anxiety scores and somatic anxiety scores by Hamilton anxiety scale （HAMA）, before and after taking medicine 2,4,8 weeks, and observed the main adverse drug reactions after had the medicine 2,8 weeks by antidepressant drug adverse reaction rating scale （SERS）.Results：The HAMA total scores and somatic anxiety scores after treatment,the two groups of patients were significantly lower, with significant difference（P〈0.05 ）,the combined use of quetiapine group decreased more obviously, and the cure rate was higher than the group that singly applicated with Duloxetine（ 16.7%, 16.7% ）,there are significant difference between the two groups （P〈0.05）. And combined use of quetiapine group in treatment two weeks later they work faster than the singly applicated with Duloxetine group, with significant difference （P〈0.05）.Adverse reactions between the two groups are lighter, mostly occur in the treatment of early, after the symptomatic treatment gradually ease.Conclusion：The curative effect of Duloxetine combined use of quetiapine in the treatment of somatoform disorder was good and work fast, no increased in adverse reactions.