摘要
目的:进行安全而有效的减肥降脂食品研究具有广泛的应用价值,本文探讨了红芸豆α-淀粉酶抑制剂、决明子、山楂以及丹参等不同组合配方对小鼠的减肥降脂和降糖作用。方法:昆明种小鼠44只分为正常组、饲料1组、饲料2组、饲料3组,采用小鼠饲喂配合了芸豆α-淀粉酶抑制剂、决明子、山楂、丹参等植物药成分的高脂饲料,饲养30 d后,观察各组小鼠的体重变化及对脏器系数的影响,采用全自动生化分析仪进行肝功能丙氨酸氨基转移酶(ALT),天门冬氨酸氨基转移酶(AST),白球比,总蛋白(TP)的检测,试剂盒检测小鼠血糖(GLU)及血脂含量。结果:与正常组比较,饲料1组、饲料2组、饲料3组小鼠的体重有所降低,各脏器系数有升高,同样也有降低(P<0.05,P<0.01),各饲料组肝功能ALT,AST及TP含量明显降低,白球比明显升高,各饲料组GLU明显降低,各饲料组小鼠血脂高密度脂蛋白(HDL)含量明显升高,总胆固醇(CHOL)、甘油三酯(TG)含量明显降低,低密度脂蛋白(LDL)含量饲料2号明显升高、饲料1号和3号明显降低,均具有一定的差异(P<0.05,P<0.01)。结论:红芸豆α-淀粉酶抑制剂,决明子和山楂三者搭配具有良好的减肥降脂和降糖效果。
Objective: To study the effect of different combinations of herbal medicines and foods on weight loss, glucose and lipid-lowering, this is beneficial to humans and would have a broad application value. Method: Fouty-four Kunming mice were divided into the control group and different combination groups [containing different concents of a-amylase inhibitor extracted from red kidney bean, Cassiae Semen, Cratagei Fructus (Crataegus) and Radix et Rhizoma]. The body weight and organ coefficient were evaluated, the lipid, total cholesterol, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin/globulin, total protein (TP), blood sugarg (glucose, GLU) and blood fat were tested after 30-day treatment. Result: Compared with the normal group, the body weight declined, organ coefficient changed (P 〈 0.05, P 〈 0.01 ) , the ALT, AST arid TP contents reduced, albumin/globulin values raised, GLU level reduced, high-density lipoprotein raised, total cholesterol and triglyceride declined in all combination groups ( P 〈 0.05, P 〈 0.01 ). Different effects on low density lipoprotein were obtained from the different combination groups (P 〈0.05, P 〈 0.01 ). Conclusion: The experiment results showed that the a-amylase inhibitor played a significant role in reducing body weight, glucose and lipid-lowering when combined with cassia seed, hawthorn and red sage root.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2015年第4期129-133,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(31160244)
云南省教育厅重大专项(ZD2011008)
云南省生物能源持续开发利用教育部工程研究中心及云南省生物质能与环境生物技术重点实验室联合开放基金项目(20100506)
关键词
红芸豆α-淀粉酶抑制剂
决明子
山楂
丹参
减肥
降糖脂
α-amylase inhibitor of kidney bean
Cassiae Semen
Cratagei Fructus
SolviaeMiltionhizae Rodix et Rhizoma
reducing body weight
glucose and lipid lowering