儿童视网膜母细胞瘤治疗进展

Recent advances of treatment in children with retinoblastoma

视网膜母细胞瘤（RB）是小儿最常见的眼内恶性肿瘤，可单眼或双眼发病，40％的患儿具有遗传性。临床上有化学减容治疗、眼动脉内治疗、放疗、眼球摘除术、基因治疗及冷冻疗法、激光光凝、温热治疗等局部治疗方法。目前随着早期诊治技术的发展，化学减容疗法联合局部治疗越来越受到重视，已成为RB的治疗趋势，不但提高了患儿生存率，而且达到了保留眼球和保存视力的目的，从而提高了患儿的生活质量。

Retinoblastoma（RB） is the most common intraocular tnalignancy in children. The tumor can originate in one or both eyes. About 40% of children with RB have inherited form of the disease. The treatment options available for RB include chemoreduction therapy, intra - arterial chemotherapy, radiotherapy, enucleation, genetherapy and focal therapies such as cryotherapy, laser photocoagulation, transpupillary thermotherapy. Currently, with the progress of early diagnosis and treatment, chemotherapy combined focal therapies play an important role in the treatment, which not only improve the survival rates of RB children,but also improve the children＇s life qualities with salvaging the eye and vision.