造血干细胞移植后中枢神经系统并发症

Central nervous system compfications after hematopoietic stem cell transplantation

造血干细胞移植（HSCT）已被广泛用于治疗一些遗传性或获得性良、恶性疾病，但移植后患者出现各种严重甚至致死性中枢神经系统（CNS）并发症的概率高达11％-59％。现就引起HSCT患者CNS并发症的主要原因，如感染、药物毒性、移植物抗宿主病相关性脑血管病变、代谢性脑病和CNS疾病复发等进行讨论，以加强HSCT相关人员对CNS并发症的早期认识，及帮助于改善患者的预后。

Hematopoietic stem cell transplantation （HSCT） has been widely performed for patients with various genetic and acquired malignant and non - malignant diseases. Central nervous system （CNS） complications are considered an important cause of morbidity and mortality after HSCT. This review discuss the main causes of CNS after HSCT such as infection, drug toxicity, graft -versus -host disease, metabolic encephalopathy, neurologic relapses ate, so as to benefit the early recognition of CNS complications and to improve the prognosis of patients after HSCT.