广州人群幽门螺杆菌感染与血脂异常的相关性

Correlation between Helicobacter pylori infection and hyperlipidemia in residents of Guangzhou city

目的探讨广州地区体检人群幽门螺杆菌(helicobacter pylori,Hp)感染与血脂的关系。方法使用13C尿素呼气试验对520名体检人员进行Hp检测,并检测血脂、血压、体质量指数等,对结果进行统计学分析。结果广州地区健康体检人群Hp感染率为38.65%,男性感染率为41.82%,女性感染率为33.66%。男性及女性感染率比较,差异无统计学意义(χ2=3.469,P>0.05)。Hp阳性组血清总胆固醇,三酰甘油,低密度脂蛋白胆固醇,载脂蛋白-B浓度较Hp阴性组明显升高,差异有统计学意义(P<0.01)。血脂正常组及血症异常组Hp感染率分别为31.7%和52.9%,两组比较差异有统计学意义(χ2=21.74,P<0.01)。Logistic回归分析显示Hp感染、年龄、舒张压是高脂血症的危险因素。结论 Hp感染影响了血脂代谢,是血脂异常的危险因素之一,防治Hp感染可能有利于减少高脂血症及其相关疾病的发生。

Objectives To discuss the relationship between Helicobacter pylori（Hp） infection and concentration of blood lipid in Guangzhou residents undergoing physical examination. Methods13C-urea breath test was used to detect Hp infection in 520 people undergoing physical examination. Other indexes include blood lipid,blood pressure,body mass index（BMI） were also detected. All the indexes were statistically analyzed. Results The infection rate of Hp in Guangzhou residents undergoing physical examination was 38.65%. The infection rate of male was 41.82% and female was33.66%. There was no significant difference in Hp infection rate between male and female（χ^2=3.469,P〉0.05）. Serum concentrations of total cholesterol（TC）,triglycerides（TG）,low-density lipoprotein cholesterol（LDL-C） and apolipoprotein B（APO-B） in Hp-positive group were significantly higher than those in Hp-negative group（P〈0.01）. Difference in Hp infection rate between normal blood lipid group and abnormal blood lipid group was significant（31.7% vs. 52.9%,χ^2=21.74,P〈0.01）. Logistic regression analysis indicated that Hp infection,age,diastolic blood pressure were risk factors of hyperlipidemia. Conclusions Hp infection can affect blood lipid metabolism and it is one of the risk factors of hyperlipidemia. Actively preventing Hp infection may help to reduce the occurrence of hyperlipidemia and related diseases.